The plasminogen/plasmin system, urokinase-type plasminogen activator (uPA), its receptor
(uPAR), and its inhibitor (PAI-1), influence extracellular proteolysis and cell migration in lung …

Plasminogen activator inhibitor-1 (PAI-1), the major circulating inhibitor of urokinase
[urokinase-type plasminogen activator (uPA)], has been linked to the pathogenesis of lung …

Urokinase plasminogen activator (uPA) is a serine protease that catalyzes the conversion of
plasminogen to plasmin. The plasminogen/plasmin system includes the uPA, its receptor …

Urokinase-type plasminogen activator (uPA) is a serine protease that plays a major role in
diverse physiological and pathological processes. Studies from our laboratory have shown …

The urokinase-type plasminogen activator (uPA) interacts with its receptor (uPAR) to
promote local proteolysis as well as cellular proliferation and migration. These functions …

Interaction between the urokinase-type plasminogen activator (uPA) and its receptor (uPAR)
localizes cellular proteolysis and promotes cellular proliferation and migration. The …

The plasminogen activator inhibitor type–1 (PAI-1) effectively blocks the activities of free and
receptor-bound urokinase-type plasminogen activator. Incubation of cultured human pleural …

Gene transfer techniques were utilized to evaluate the role of urokinase-type plasminogen
activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) in enhancing or preventing …

The plasminogen activator cascade initiated by urokinase type plasminogen activator (u-PA)
is involved in extracellular matrix degradation during the tumor invasion process. The …

In vitro studies have demonstrated that the binding of urokinase-type plasminogen activator
(uPA) to its cell surface receptor (uPAR) greatly accelerates plasminogen activation …