Background Acute lung injury (ALI) is a potentially fatal lung disease with few treatment
options. Platelet activation is a key component of ALI pathophysiology and may provide an …

Objectives: Platelet activation plays an active role in the pathogenesis of acute respiratory
distress syndrome. In our prior study of 575 patients at high risk for acute respiratory distress …

Background Antiplatelet agents are commonly used for cardiovascular diseases, but their
pleiotropic effects in critically ill patients are controversial. We therefore performed a meta …

Objective: To evaluate the association between prehospitalization aspirin therapy and
incident acute lung injury in a heterogeneous cohort of at-risk medical patients. Design: This …

Objective: To determine whether prehospital antiplatelet therapy was associated with
reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt …

Objective: Platelet activation has been implicated in microvascular thrombosis and organ
failure. We tested the hypothesis that antiplatelet drugs favorably affect outcome in patients …

Acute respiratory distress syndrome (ARDS) is a common and devastating syndrome that
contributes to serious morbidities and mortality in critically ill patients. No known …

Background. Sepsis is characterized by dysfunctional activation of platelets, and antiplatelet
therapy could improve the outcomes of septic patients. Methods. We performed a …

Background Antiplatelet therapy may attenuate the undesirable effects of platelets on the
inflammatory cascades in critical illness. The objective of this study was to evaluate the …

Rationale: Acute respiratory distress syndrome (ARDS) is a devastating illness with limited
therapeutic options. A better understanding of early biochemical and immunological events …