Unraveling the role of angiogenesis in cancer ecosystems

I Zuazo-Gaztelu, O Casanovas - Frontiers in Oncology, 2018 - frontiersin.org
Activation of the tumor and stromal cell-driven angiogenic program is one of the first
requirements in the tumor ecosystem for growth and dissemination. The understanding of …

Tumour vascularization: sprouting angiogenesis and beyond

F Hillen, AW Griffioen - Cancer and Metastasis Reviews, 2007 - Springer
Tumour angiogenesis is a fast growing domain in tumour biology. Many growth factors and
mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of …

Tumor cell-mediated neovascularization and lymphangiogenesis contrive tumor progression and cancer metastasis

Z Cao, B Shang, G Zhang, L Miele, FH Sarkar… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Robust neovascularization and lymphangiogenesis have been found in a variety of
aggressive and metastatic tumors. Endothelial sprouting angiogenesis is generally …

Molecular mechanisms of tumor vascularization

P Auguste, S Lemiere, F Larrieu-Lahargue… - Critical reviews in …, 2005 - Elsevier
Tumor angiogenesis is a fast growing sub-domain of angiogenesis research and tumor
biology. Basic mechanisms have been unraveled and many key players identified. For many …

Angiogenesis in spontaneous tumors and implications for comparative tumor biology

C Benazzi, A Al-Dissi, CH Chau… - The Scientific World …, 2014 - Wiley Online Library
Blood supply is essential for development and growth of tumors and angiogenesis is the
fundamental process of new blood vessel formation from preexisting ones. Angiogenesis is …

Microenvironmental regulation of tumour angiogenesis

M De Palma, D Biziato, TV Petrova - Nature Reviews Cancer, 2017 - nature.com
Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

Inducing angiogenesis, a key step in cancer vascularization, and treatment approaches

H Saman, SS Raza, S Uddin, K Rasul - Cancers, 2020 - mdpi.com
Angiogenesis is a term that describes the formation of new blood and lymphatic vessels from
a pre-existing vasculature. This allows tumour cells to acquire sustenance in the form of …

Escaping antiangiogenic therapy: Strategies employed by cancer cells

MP Pinto, P Sotomayor, G Carrasco-Avino… - International journal of …, 2016 - mdpi.com
Tumor angiogenesis is widely recognized as one of the “hallmarks of cancer”.
Consequently, during the last decades the development and testing of commercial …

Milestones in tumor vascularization and its therapeutic targeting

M De Palma, D Hanahan - Nature Cancer, 2024 - nature.com
Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …