Inflammatory cytokines and chemokines as therapeutic targets in heart failure

A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Proinflammatory cytokines in heart failure: double-edged swords

M Hedayat, MJ Mahmoudi, NR Rose, N Rezaei - Heart failure reviews, 2010 - Springer
Increased circulating and intracardiac levels of proinflammatory cytokines have been
associated with chronic heart failure. Following an initial insult, the increased production of …

Immune modulation: role of the inflammatory cytokine cascade in the failing human heart

M Satoh, Y Minami, Y Takahashi… - Current heart failure reports, 2008 - Springer
Recent studies have determined that expression of inflammatory mediators, such as
cytokines and chemokines, is an important factor in the development and progression of …

Role of inflammation in the progression of heart failure

A Yndestad, JK Damås, E Øie, T Ueland… - Current cardiology …, 2007 - Springer
Chronic heart failure (HF) is a disorder characterized in part by immune activation and
inflammation. Thus, patients with HF have elevated levels of a number of inflammatory …

Inflammatory cytokines in heart failure: mediators and markers

L Gullestad, T Ueland, LE Vinge, A Finsen, A Yndestad… - Cardiology, 2012 - karger.com
Evidence from both experimental and clinical trials indicates that inflammatory mediators are
of importance in the pathogenesis of chronic heart failure (HF) contributing to cardiac …

Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches

L Gullestad, P Aukrust - The American journal of cardiology, 2005 - Elsevier
Accumulating evidence indicates that inflammatory mediators are important in the
pathogenesis of chronic heart failure (CHF), contributing to cardiac remodeling and …

Cytokines and myocardial dysfunction: state of the art

AA El-Menyar - Journal of cardiac failure, 2008 - Elsevier
BACKGROUND: Myocardial dysfunction has been associated with inflammation and
cytokine modulation. OBJECTIVES: The study objective was to understand the role of …

Cytokines and heart failure.

WJ Paulus - Heart failure monitor, 2000 - europepmc.org
In many forms of cardiomyopathic left ventricular (LV) dysfunction, there is a rapid
myocardial expression of pro-inflammatory cytokines such as interleukin 1, interleukin 6 and …

Cytokines in heart failure: pathogenetic mechanisms and potential treatment

Z Dibbs, K Kurrelmeyer, D Kalra, Y Seta… - Proceedings of the …, 1999 - Wiley Online Library
Recent studies have shown that patients with heart failure overexpress a class of
biologically active molecules, generically referred to as pro‐inflammatory cytokines. This …

Tumor necrosis factor-α in heart failure: an updated review

SM Schumacher, SV Naga Prasad - Current cardiology reports, 2018 - Springer
Abstract Purpose of the Review Proinflammatory cytokines are consistently elevated in
congestive heart failure. In the current review, we provide an overview on the current …