BACKGROUND: Caspases are downstream elements of apoptosis-mediating pathways
initiated by the Fas ligand/Fas receptor system which is supposed to play a central role in …

BACKGROUND: Germ cell elimination and sperm DNA fragmentation in men with primary
testiculopathies involve apoptosis‐related processes whose mechanisms are poorly …

To elucidate the mechanism of maturation arrest, known as one of the male infertility, we
addressed whether germ cell apoptosis occurs during maturation arrest, and if so, whether …

Programmed cell death is an important regulatory event in spermatogenesis. However, the
molecular events governing apoptosis have not been characterized. Using the Leydig cell …

Apoptosis of germ cells is very common in normal and injured mammalian testes. The aim of
this study was to examine the possible involvement of the Fas and Fas ligand (FasL) system …

Apoptosis appears to have an essential role in the control of germ cell number in testes.
During spermatogenesis germ cell deletion has been estimated to result in the loss of up to …

OBJECTIVE: To provide evidence that the Fas-mediated apoptotic process may participate
in developing hypospermatogenesis, such as maturation arrest (MA) and Sertoli cell–only …

The purpose of the present study was to examine the possible involvement of caspase-3
and caspase-activated deoxyribonuclease in rat testicular germ cell apoptosis resulting from …

A growing body of evidence demonstrates that germ cell death both spontaneous (during
normal spermatogenesis) and that induced by suppression of hormonal support or …

Germ cell apoptosis is very common during various stages of mammalian testicular
development. However, our understanding of the mechanisms underlying male germ cell …