Protective effect of lycopene on high-fat diet-induced cognitive impairment in rats

Z Wang, J Fan, J Wang, Y Li, L Xiao, D Duan… - Neuroscience letters, 2016 - Elsevier
A Western diet, high in saturated fats, has been linked to the development of cognitive
impairment. Lycopene has recently received considerable attention for its potent protective …

Lycopene attenuates Western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut–liver–brain axis

J Wang, Z Wang, B Li, Y Qiang, T Yuan, X Tan… - International Journal of …, 2019 - nature.com
Background/objectives The aim of the current study was to investigate the inhibitory effect of
lycopene (LYC), a major carotenoid present in tomato, on high-fat and high-fructose western …

Lycopene attenuates D-galactose-induced cognitive decline by enhancing mitochondrial function and improving insulin signaling in the brains of female CD-1 mice

J Wang, Y Shen, M Li, T Li, D Shi, S Lu, F Qiu… - The Journal of Nutritional …, 2023 - Elsevier
The incidence of neurodegenerative diseases is severely increasing with ageing. Lycopene
(LYC), a carotenoid pigment, has been reported to have antioxidant, anti-inflammatory and …

Lycopene abrogates obesity-provoked hyperactivity of neurosignalling enzymes, oxidative stress and hypothalamic inflammation in female Wistar rats

RN Ugbaja, EI Ugwor, OA Dosumu, AS James… - Neurochemistry …, 2021 - Elsevier
Obesity, a global epidemic, has been strongly associated with impairment of brain function.
Lycopene has several therapeutic properties and can cross the blood-brain barrier …

The treatment combination of vitamins E and C and astaxanthin prevents high-fat diet induced memory deficits in rats

A Komaki, SA Karimi, I Salehi, A Sarihi… - Pharmacology …, 2015 - Elsevier
Cognitive function is impaired by imbalanced diet consumption. High-fat diet (HFD) induces
oxidative stress and metabolic disorders, which results in neuronal damage and interferes …

Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats

Q Yin, Y Ma, Y Hong, X Hou, J Chen, C Shen, M Sun… - …, 2014 - Elsevier
Fructose intake is linked with the increasing prevalence of insulin resistance, and insulin
resistance links Alzheimer's disease with impaired insulin signaling, oxidative damage …

Effects of Hypericum scabrum extract on learning and memory and oxidant/antioxidant status in rats fed a long-term high-fat diet

A Ganji, I Salehi, M Nazari, M Taheri, A Komaki - Metabolic brain disease, 2017 - Springer
A high-fat diet (HFD) causes deficits in learning and memory by increasing oxidative stress.
Antioxidants are known to improve learning and memory. Since Hypericum scabrum (H …

Mechanisms of multiple neurotransmitters in the effects of Lycopene on brain injury induced by Hyperlipidemia

W Yang, Z Shen, S Wen, W Wang, M Hu - Lipids in health and disease, 2018 - Springer
Background Lycopene is a kind of carotenoid, with a strong capacity of antioxidation and
regulating the bloodlipid. There has been some evidence that lycopene has protective …

Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway

B Zhao, B Ren, R Guo, W Zhang, S Ma, Y Yao… - Food and Chemical …, 2017 - Elsevier
Oxidative stress, considered as a major culprit in brain aging, triggers cognitive and memory
impairment. Lycopene (LYC), a carotenoid pigment, possesses potent antioxidative, anti …

In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment

Y Lei, J Chen, W Zhang, W Fu, G Wu, H Wei, Q Wang… - Food chemistry, 2012 - Elsevier
The potential of three natural flavonols (galangin, kaempferol and myricetin) to protect
against d-galactose-induced cognitive impairment in mice was investigated. After 8weeks …