The dual role of Nrf2 in nonalcoholic fatty liver disease: regulation of antioxidant defenses and hepatic lipid metabolism

SS Chambel, A Santos-Gonçalves… - BioMed research …, 2015 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease with ever‐growing
incidence in the industrialized world. It starts with the simple accumulation of lipids in the …

Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications

I Khan, M Hussain, B Jiang, L Zheng, Y Pan, J Hu… - Progress in lipid …, 2023 - Elsevier
Abstract Recently, omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have
gained substantial interest due to their specific structure and biological functions. Humans …

Activation of the Nrf2 cell defense pathway by ancient foods: disease prevention by important molecules and microbes lost from the modern western diet

DR Senger, D Li, SC Jaminet, S Cao - PloS one, 2016 - journals.plos.org
The Nrf2 (NFE2L2) cell defense pathway protects against oxidative stress and disorders
including cancer and neurodegeneration. Although activated modestly by oxidative stress …

Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARγ signaling

S Su, G Wu, X Cheng, J Fan, J Peng, H Su, Z Xu… - Free Radical Biology …, 2018 - Elsevier
Polychlorinated biphenyls (PCBs) exposure is closely associated with obesity and diabetes.
However, the mechanism of PCBs-induced adiposity and insulin resistance is not clear and …

When NRF2 talks, who's listening?

N Wakabayashi, SL Slocum, JJ Skoko… - Antioxidants & redox …, 2010 - liebertpub.com
Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental
and endogenous stresses and serves to render animals resistant to chemical …

Discovery of eicosapentaenoic acid esters of hydroxy fatty acids as potent Nrf2 activators

SG B. Gowda, H Fuda, T Tsukui, H Chiba, SP Hui - Antioxidants, 2020 - mdpi.com
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of
biologically active lipids with anti-inflammatory and anti-diabetic properties. Despite the …

NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet

Y Tanaka, LM Aleksunes, RL Yeager, MA Gyamfi… - … of Pharmacology and …, 2008 - ASPET
NF-E2-related factor 2 (Nrf2) is a transcription factor that is activated by oxidative stress and
electrophiles that regulates the expression of numerous detoxifying and antioxidant genes …

Dietary supplementation with fish oil or conjugated linoleic acid relieves depression markers in mice by modulation of the Nrf2 pathway

L Cigliano, MS Spagnuolo, F Boscaino… - Molecular nutrition & …, 2019 - Wiley Online Library
Inflammation and oxidative stress play an important role in the pathogenesis of depressive
disorders and nuclear erythroid related factor 2 (Nrf2), a regulator of RedOx homeostasis …

[HTML][HTML] NRF2 is essential for adaptative browning of white adipocytes

M Bauzá-Thorbrügge, E Peris, S Zamani, P Micallef… - Redox Biology, 2023 - Elsevier
White adipose tissue browning, defined by accelerated mitochondrial metabolism and
biogenesis, is considered a promising mean to treat or prevent obesity-associated metabolic …

n− 3 PUFA and membrane microdomains: a new frontier in bioactive lipid research

DWL Ma, J Seo, KC Switzer, YY Fan… - The Journal of nutritional …, 2004 - Elsevier
In recent years, our understanding of the plasma membrane has changed considerably as
our knowledge of lipid microdomains has expanded. Lipid microdomains include structures …