The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation

I de Bus, R Witkamp, H Zuilhof, B Albada… - Prostaglandins & other …, 2019 - Elsevier
Notwithstanding the ongoing debate on their full potential in health and disease, there is
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …

Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy

L Shen, Y Yang, T Ou, CCC Key, SH Tong… - Journal of lipid …, 2017 - ASBMB
Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how nucleotide-
binding oligomerization domain leucine-rich repeat-containing receptor protein (NLRP3) …

Polyunsaturated fatty acids: conversion to lipid mediators, roles in inflammatory diseases and dietary sources

JL Harwood - International Journal of Molecular Sciences, 2023 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are important components of the diet of mammals. Their
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …

N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis

R Valenzuela, A Espinosa, D González-Mañán… - 2012 - journals.plos.org
Omega-3 (n-3) long-chain polyunsaturated fatty acids (n-3 LCPUFA) are associated with
several physiological functions, suggesting that their administration may prevent non …

Endogenous Generation and Signaling Actions of Omega‐3 Fatty Acid Electrophilic Derivatives

C Cipollina - BioMed research international, 2015 - Wiley Online Library
Dietary omega‐3 polyunsaturated fatty acids (PUFAs) are beneficial for a number of
conditions ranging from cardiovascular disease to chronic airways disorders …

Narrative Review of n-3 Polyunsaturated Fatty Acid Supplementation upon Immune Functions, Resolution Molecules and Lipid Peroxidation

GP Zaloga - Nutrients, 2021 - mdpi.com
Fish oil supplementation is commonplace in human nutrition and is being used in both
enteral and parenteral formulations during the treatment of patients with a large variety of …

A lipidomic study on the regulation of inflammation and oxidative stress targeted by marine ω-3 PUFA and polyphenols in high-fat high-sucrose diets

G Dasilva, M Pazos, E García-Egido… - The Journal of …, 2017 - Elsevier
The ability of polyphenols to ameliorate potential oxidative damage of ω-3 PUFAs when they
are consumed together and then, to enhance their potentially individual effects on metabolic …

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

R Varì, M D'Archivio, C Filesi, S Carotenuto… - The Journal of …, 2011 - Elsevier
Protocatechuic acid (PCA) is a main metabolite of anthocyanins, whose daily intake is much
higher than that of other polyphenols. PCA has biological effects, eg, it induces the …

Biological and pathophysiological roles of end-products of DHA oxidation

VP Yakubenko, TV Byzova - … et Biophysica Acta (BBA)-Molecular and Cell …, 2017 - Elsevier
Background Polyunsaturated fatty acids (PUFA) are known to be present and/or enriched in
vegetable and fish oils. Among fatty acids, n-3 PUFA are generally considered to be …

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

GP Sykiotis, IG Habeos, AV Samuelson… - Current Opinion in …, 2011 - journals.lww.com
The emerging role of Nrf2 as an effector of metabolic and longevity signals offers new
therapeutic perspectives. The potential impact of pharmacological manipulation of Nrf2 …