[HTML][HTML] Docosahexaenoic acid esters of hydroxy fatty acid is a novel activator of NRF2

SG B. Gowda, T Tsukui, H Fuda, Y Minami… - International Journal of …, 2021 - mdpi.com
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a new class of endogenous lipids with
interesting physiological functions in mammals. Despite their structural diversity and links …

Omega-3 polyunsaturated fatty acids: anti-inflammatory and anti-hypertriglyceridemia mechanisms in cardiovascular disease

T Shibabaw - Molecular and Cellular Biochemistry, 2021 - Springer
Cardiovascular disease (CVD) is the world's most recognized and notorious cause of death.
It is known that increased triglyceride-rich lipoproteins (TRLs) and remnants of triglyceride …

Omega-3 fatty acid supplementation influences the whole blood transcriptome in women with obesity, associated with pro-resolving lipid mediator production

A Polus, B Zapala, U Razny, A Gielicz… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) may reduce low-grade inflammation associated with obesity …

[HTML][HTML] Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021

I Djuricic, PC Calder - Nutrients, 2021 - mdpi.com
Oxidative stress and inflammation have been recognized as important contributors to the risk
of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate …

[HTML][HTML] The biochemistry of n-3 polyunsaturated fatty acids* 210

DB Jump - Journal of Biological Chemistry, 2002 - ASBMB
Dietary n-3 polyunsaturated fatty acids (n-3 PUFA) 1 have effects on diverse physiological
processes impacting normal health and chronic disease, such as the regulation of plasma …

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

E Kansanen, HK Jyrkkänen, AL Levonen - Free Radical Biology and …, 2012 - Elsevier
Unsaturated fatty acids are prone to radical reactions that occur in biological situations
where extensive formation of reactive oxygen and nitrogen species (ROS and RNS) takes …

[HTML][HTML] Oxidative stress and non-alcoholic fatty liver disease: effects of omega-3 fatty acid supplementation

J Yang, M Fernández-Galilea, L Martínez-Fernández… - Nutrients, 2019 - mdpi.com
Aging is a complex phenomenon characterized by the progressive loss of tissue and organ
function. The oxidative-stress theory of aging postulates that age-associated functional …

Nrf2-mediated antioxidant defense and peroxiredoxin 6 are linked to biosynthesis of palmitic acid ester of 9-hydroxystearic acid

O Kuda, M Brezinova, J Silhavy, V Landa, V Zidek… - Diabetes, 2018 - Am Diabetes Assoc
Fatty acid esters of hydroxy fatty acids (FAHFAs) are lipid mediators with promising
antidiabetic and anti-inflammatory properties that are formed in white adipose tissue (WAT) …

Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes

S Legrand-Poels, N Esser, L L'homme… - Biochemical …, 2014 - Elsevier
Free fatty acids (FFAs) are metabolic intermediates that may be obtained through the diet or
synthesized endogenously. In addition to serving as an important source of energy, they …

[HTML][HTML] Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals

AL Stefanson, M Bakovic - Nutrients, 2014 - mdpi.com
It has become increasingly evident that chronic inflammation underpins the development of
many chronic diseases including cancer, cardiovascular disease and type 2 diabetes …