C3 is a central protein of the complement system, which is important to immune defense and
provides a link between innate and adaptive immunity. Three pathways of complement …

As the most abundant component of the complement system, C3 and its proteolytic
derivatives serve essential roles in the function of all three complement pathways. Central to …

C1 is the multimolecular protease that triggers activation of the classical pathway of
complement, a major element of antimicrobial host defense also involved in immune …

The complement system is a crucial part of innate immune defenses against invading
pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick …

C3 plays a critical role in both pathways of complement activation due to its ability to bind to
numerous other complement proteins. In addition, its interactions with several cell surface …

C1, the multimolecular protease that triggers the classical pathway of complement, has a
major role in the host defense against pathogens. It also participates in other biological …

As part of the innate immune system, the complement system recognises a wide range of
non-self structures present on pathogens or altered self cells. Its activation elicits proteolytic …

Complement protein C3 is a central molecule in the complement system whose activation is
essential for all the important functions performed by this system. After four decades of …

Many of the biological activities of the complement system are mediated by C3, the third
complement component, and its proteolytic fragments. At the same time, several of the …

The mammalian complement system is a phylogenetically ancient cascade system that has
a major role in innate and adaptive immunity. Activation of component C3 (1,641 residues) is …