[HTML][HTML] Renin and cardiovascular disease: Worn-out path, or new direction
G Alreja, J Joseph - World journal of cardiology, 2011 - ncbi.nlm.nih.gov
Inhibition of the renin angiotensin system has beneficial effects in cardiovascular prevention
and treatment. The advent of orally active direct renin inhibitors adds a novel approach to …
and treatment. The advent of orally active direct renin inhibitors adds a novel approach to …
Renin: friend or foe?
MJ Brown - Heart, 2007 - heart.bmj.com
Renin maintains blood pressure through vasoconstriction when there is inadequate salt to
maintain volume. In populations where blood pressure is more often high than low, and …
maintain volume. In populations where blood pressure is more often high than low, and …
Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease
CVS Ram - Future Cardiology, 2009 - Taylor & Francis
Despite the last three decades of progress in improving cardiovascular outcomes via renin–
angiotensin–aldosterone system (RAAS) blockade in hypertensive patients, substantial …
angiotensin–aldosterone system (RAAS) blockade in hypertensive patients, substantial …
Cardiovascular and renal pathologic implications of prorenin, renin, and the (pro) renin receptor: promising young players from the old renin-angiotensin-aldosterone …
P Balakumar, G Jagadeesh - Journal of cardiovascular …, 2010 - journals.lww.com
The overactivation of the renin-angiotensin-aldosterone system accounts for many
cardiovascular and renal abnormalities. At several levels of its cascade, the renin …
cardiovascular and renal abnormalities. At several levels of its cascade, the renin …
Importance of renin in blood pressure regulation and therapeutic potential of renin inhibition
Despite improvements in its detection and treatment, hypertension remains a significant
public health problem worldwide. In recent years, many international hypertension societies …
public health problem worldwide. In recent years, many international hypertension societies …
Circulating versus tissue renin-angiotensin system: on the origin of (pro) renin
M Krop, AH Jan Danser - Current hypertension reports, 2008 - Springer
Angiotensin synthesis at tissue sites is well established, and interference with tissue
angiotensin is now believed to underlie the beneficial effects of renin-angiotensin system …
angiotensin is now believed to underlie the beneficial effects of renin-angiotensin system …
The (pro) renin receptor: therapeutic consequences
G Nguyen, AHJ Danser - Expert opinion on investigational drugs, 2006 - Taylor & Francis
It is generally assumed that the beneficial effects of renin–angiotensin system blockers in
cardiovascular disease are due to blockade of the generation or action of angiotensin at …
cardiovascular disease are due to blockade of the generation or action of angiotensin at …
The increase in renin during renin inhibition: does it result in harmful effects by the (pro) renin receptor?
AH Danser - Hypertension Research, 2010 - nature.com
Renin inhibitors, similar to all renin–angiotensin system (RAS) blockers, increase the
plasma concentration of renin because they attenuate the negative feedback effect of …
plasma concentration of renin because they attenuate the negative feedback effect of …
Critical review of prorenin and (pro) renin receptor research
DJ Campbell - Hypertension, 2008 - Am Heart Assoc
The renin-angiotensin system (RAS) plays an important role in cardiovascular and renal
physiology and disease, and the benefits of angiotensin-converting enzyme inhibitor …
physiology and disease, and the benefits of angiotensin-converting enzyme inhibitor …
Renin inhibition: new potential for an old therapeutic target
(RAS) as a pathogenetic factor in various tissues, including the kidney, heart, and eye. 1
These studies have indicated that blockade of the RAS is an important therapeutic strategy …
These studies have indicated that blockade of the RAS is an important therapeutic strategy …