Inhibition of the renin angiotensin system has beneficial effects in cardiovascular prevention
and treatment. The advent of orally active direct renin inhibitors adds a novel approach to …

Renin maintains blood pressure through vasoconstriction when there is inadequate salt to
maintain volume. In populations where blood pressure is more often high than low, and …

Despite the last three decades of progress in improving cardiovascular outcomes via renin–
angiotensin–aldosterone system (RAAS) blockade in hypertensive patients, substantial …

The overactivation of the renin-angiotensin-aldosterone system accounts for many
cardiovascular and renal abnormalities. At several levels of its cascade, the renin …

Despite improvements in its detection and treatment, hypertension remains a significant
public health problem worldwide. In recent years, many international hypertension societies …

Angiotensin synthesis at tissue sites is well established, and interference with tissue
angiotensin is now believed to underlie the beneficial effects of renin-angiotensin system …

It is generally assumed that the beneficial effects of renin–angiotensin system blockers in
cardiovascular disease are due to blockade of the generation or action of angiotensin at …

Renin inhibitors, similar to all renin–angiotensin system (RAS) blockers, increase the
plasma concentration of renin because they attenuate the negative feedback effect of …

The renin-angiotensin system (RAS) plays an important role in cardiovascular and renal
physiology and disease, and the benefits of angiotensin-converting enzyme inhibitor …

(RAS) as a pathogenetic factor in various tissues, including the kidney, heart, and eye. 1
These studies have indicated that blockade of the RAS is an important therapeutic strategy …