One of the main functions of the airway epithelium is to inactivate and remove infectious
particles from inhaled air and thereby prevent infection of the distal lung. This function is …

The airway surface liquid (ASL) is a thin sheet of fluid that covers the luminal aspect of the
airway epithelium. The ASL is a site of several first-line host defenses, and its composition is …

Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

Cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-dependent airway
epithelial bicarbonate transport is hypothesized to participate in airway surface liquid pH …

Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …

Two Cl− conductances have been described in the apical membrane of both human and
murine proximal airway epithelia that are thought to play predominant roles in airway …

A key aspect of the lung's innate defense system is the ability of the superficial epithelium to
regulate airway surface liquid (ASL) volume to maintain a 7-μm periciliary liquid layer (PCL) …

The pathogenesis of cystic fibrosis (CF) airways infection is unknown. Two hypotheses,"
hypotonic [low salt]/defensin" and" isotonic volume transport/mucus clearance," attempt to …

Airway surface liquid (ASL) pH has been proposed to be important in the pathophysiology of
cystic fibrosis, asthma, and cough. Ratio image analysis was used to measure pH in the ASL …