BACKGROUND AND PURPOSE We investigated the effect of the phosphodiesterase‐5
inhibitor, tadalafil, on the acute hypernociception in rat models of arthritis. EXPERIMENTAL …

There has been much interest in strategies which modulate tumour necrosis factor-α (TNF-α)
levels and/or function in rheumatoid arthritis. The elevation of intracellular levels of cyclic …

The anti-nociceptive effect of thalidomide on zymosan-induced articular knee joint
incapacitation in rats was investigated. Thalidomide (5–45mg/kg), given 30min before but …

FK506 and cyclosporin A (CsA) are immunosuppressive drugs, that specifically inhibit T‐cell
activation via calcineurin inhibition. This study was undertaken to investigate whether …

Statins, the cholesterol lowering drugs, have been shown to exhibit anti-inflammatory
properties. The aim of the present study was to evaluate the efficacy of atorvastatin in …

Introduction Peroxisome proliferator-activated receptor (PPAR) agonists are widely used
drugs in the treatment of diabetes and dyslipidemia. In addition to their metabolic effects …

Dual effect of nitric oxide in articular inflammatory pain in zymosan-induced arthritis in rats -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Mice have been used as animal model to study mechanisms underlying inflammatory and
immune diseases. The present study describes a model of joint inflammation-induced …

Dexketoprofen and tramadol, alone or in combination, were evaluated after oral or intra-
articular administration on knee osteoarthritis nociception induced by intra-articular (i. ar.) …

Objectives. The study was designed to investigate the analgesic effects and mechanisms of
acetaminophen (paracetamol) in symptomatic osteoarthritis (OA) of the knee. Methods …