A major obstacel to the study of mammalian development, and to the practical application of
knowledge gained from it in the clinic during therapeutic in vitro fertilisation and embryo …

Free radicals, once the preserve of chemists, are now recognized as playing a central role in
many biological systems. They are formed as an inevitable by-product of aerobic respiration …

Analysis over the first 48 h of development in vitro from the one-cell stage to the early four-
cell stage indicated that (i) ethylenediaminetetraacetic acid (EDTA) exerts the major …

Oxidative damage due to the production of reactive oxygen species (ROS) is one of a
number of culture‐induced stresses which may compromise preimplantation embryo …

OBJECTIVE: To compare the effects of atmospheric and physiologic oxygen concentrations
on the global patterns of gene expression during mouse preimplantation development …

Previous studies have suggested that oxygen toxicity is closely related to the developmental
blockage of embryos cultured in vitro. In this study, to obtain an actual proof of the increase …

In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …

The toxic effects of oxygen on the embryos of various animal species are reviewed.
Methodologies for assessing embryonic damage are discussed and possible ways of …

Mouse zygotes from a strain combination which fails to undergo cleavage in vitro (the 2-cell
block) were cultured in a variety of media, using either tow (5%) or normal (20%) oxygen …

Oxidative stress is involved in the aetiology of defective embryo development. Reactive
oxygen species (ROS) may originate from embryo metabolism and/or embryo surroundings …