Examining the Effect of Metformin on Cell Death Mechanisms in Relation to Hippo Signaling in MDA-MB-231 Breast Cancer Cells
Ö Rencuzoğulları, ZG Sonalp - Cumhuriyet Science Journal, 2024 - csj.cumhuriyet.edu.tr
Breast cancer is one of the most common cancer types in women in the world and our
country. Antitumorigenic activity is achieved with various therapeutic drugs by directly …
country. Antitumorigenic activity is achieved with various therapeutic drugs by directly …
Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitro
ZY Gao, Z Liu, MH Bi, JJ Zhang… - Experimental and …, 2016 - spandidos-publications.com
Breast cancer is the most commonly occurring cancer and second leading cause of mortality
in women. Metformin is a widely prescribed anti-hyperglycemic drug, which is emerging as a …
in women. Metformin is a widely prescribed anti-hyperglycemic drug, which is emerging as a …
Metformin promotes apoptosis in primary breast cancer cells by downregulation ofcyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism
Background/aim: In the present study we aimed to figure out the effect of metformin on the
expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer …
expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer …
Effect of metformin on the proliferation, apoptosis, invasion and autophagy of ovarian cancer cells
G Zou, J Bai, D Li, Y Chen - Experimental and …, 2019 - spandidos-publications.com
The present study evaluated the effect of metformin on the SKOV3 ovarian cancer cell line
and investigated the underlying mechanism. The inhibitory rate of SKOV3 cells was …
and investigated the underlying mechanism. The inhibitory rate of SKOV3 cells was …
The antiproliferative potential and mechanism of action of metformin in MCF-7 cells
Aim: The current study aimed to investigate the potential antiproliferative activity of
metformin, the effective concentration range, and the mechanism of action. Materials & …
metformin, the effective concentration range, and the mechanism of action. Materials & …
[PDF][PDF] Antidiabetic drug metformin mitigates ovarian cancer SKOV3 cell growth by triggering G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signaling pathway
YL Fu, QH Zhang, XW Wang… - Eur Rev Med Pharmacol …, 2017 - europeanreview.org
OBJECTIVE: Metformin is one of most extensively prescribed oral hypoglycemic drug and
has received increased attention in recent times for its antitumorigenic potential. Many …
has received increased attention in recent times for its antitumorigenic potential. Many …
[HTML][HTML] Combination of metformin and gallic acid induces autophagy and apoptosis in human breast cancer cells
M Haghshenas, N Firouzabadi… - Research in …, 2023 - journals.lww.com
Background and purpose: Breast cancer is the most common type of cancer and one of the
major causes of death among women. Many reports propose gallic acid as a candidate for …
major causes of death among women. Many reports propose gallic acid as a candidate for …
Effects of metformin on cancers in experimental and clinical studies: Focusing on autophagy and AMPK/mTOR Signaling Pathways
MY Zamanian, M Golmohammadi… - Cell Biochemistry …, 2024 - Wiley Online Library
Metformin (MET) is a preferred drug for the treatment of type 2 diabetes mellitus. Recent
studies show that apart from its blood glucose‐lowering effects, it also inhibits the …
studies show that apart from its blood glucose‐lowering effects, it also inhibits the …
Metformin inhibits proliferation and promotes apoptosis of HER-2 positive breast cancer cells possibly through the Hippo-YAP pathway
Y Xu, T Xu, Y Xiong, J Huang - Nan Fang yi ke da xue xue bao …, 2022 - europepmc.org
Objective To investigate the effect of metformin on the proliferation and apoptosis of HER-2-
positive breast cancer cell line SKBR3 and explore the possible mechanism of its action …
positive breast cancer cell line SKBR3 and explore the possible mechanism of its action …
Metformin induces apoptosis and alters cellular responses to oxidative stress in Ht29 colon cancer cells: preliminary findings
P Sena, S Mancini, M Benincasa, F Mariani… - International journal of …, 2018 - mdpi.com
Accumulating evidence suggests that metformin, used as an antidiabetic drug, possesses
anti-cancer properties. Metformin reduced the incidence and growth of experimental tumors …
anti-cancer properties. Metformin reduced the incidence and growth of experimental tumors …