Pulmonary arterial hypertension (PAH) is a devastating disease characterized by
progressive increases in pulmonary vascular resistance that can ultimately lead to right …

Background Exercise capacity is impaired in pulmonary arterial hypertension (PAH). We
hypothesized that cardiovascular reserve abnormalities would be associated with impaired …

Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH,
the right ventricle tends to remain adapted to afterload with increased contractility and little …

Background and aim Exercise intolerance is one of the key features of pulmonary arterial
hypertension (PAH). The main determinants of exercise impairment include hypoxemia …

Pulmonary arterial hypertension (PAH) is a fatal lung disease characterised by progressive
remodelling of the small pulmonary vessels. The daily-life activities of patients with PAH are …

Despite recent advances, the prognosis of pulmonary hypertension (PH) remains poor.
While the initial insult in PH implicates the pulmonary vasculature, the functional state …

Background—In idiopathic pulmonary arterial hypertension (IPAH), increased right
ventricular (RV) power is required to maintain cardiac output. For this, RV O2 consumption …

Pulmonary arterial hypertension (PAH) is a rare disease, which leads to the progressive loss
and remodeling of the pulmonary vessels, right heart failure, and death. Different clinical …

Pulmonary vascular diseases (PVDs) have significant morbidity and mortality. Patients
present with either acute or chronic symptoms resulting from damage to the pulmonary …

Respiratory and limb muscle dysfunction is emerging as an important pathophysiological
abnormality in pulmonary arterial hypertension (PAH). Muscle abnormalities appear to occur …