Pulmonary arterial hypertension (PAH) is a progressive disease primarily affecting the
pulmonary vasculature and heart. PAH patients suffer from exercise intolerance and fatigue …

Patients affected by pulmonary arterial hypertension (PAH) show a reduced exercise
tolerance with early occurrence of dyspnoea and fatigue. The origin of functional capacity …

Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a
progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) …

Pulmonary arterial hypertension (PAH) is characterized by impaired pulmonary vascular
structure and function and is commonly associated with symptoms of dyspnea, fatigue, and …

Despite improvements in survival with disease-targeted therapies, the majority of patients
with pulmonary arterial hypertension (PAH) have persistent exercise intolerance that results …

Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV …

The right ventricle (RV) is not well suited to chronic pressure overload and often fails to
adequately compensate. Mechanisms that allow the RV to respond to acute pressure …

Introduction: Exercise intolerance in pulmonary hypertension (PH) is a major factor affecting
activities of daily living and quality of life. Evaluation strategies (ie, non-invasive and …

Given the unique and clinically ominous pathology associated with pulmonary arterial (PA)
hypertension (PH) and its implications for the eventual deterioration of right ventricular …

Coupling of right ventricular (RV) contractility to afterload is maintained at rest in the early
stages of pulmonary arterial hypertension (PAH), but exercise may unmask depleted …