Cellular senescence was first described as a physiological tumor cell suppressor
mechanism that leads to cell growth arrest with production of the senescence-associated …

Cellular senescence occurs in proliferating cells as a consequence of various triggers
including telomere shortening, DNA damage, and inappropriate expression of oncogenes …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

The senescence‐associated secretory phenotype (SASP), where senescent cells produce a
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …

Therapy-induced cellular senescence is a state of stable growth arrest induced by common
cancer treatments such as chemotherapy and radiation. In an oncogenic context, therapy …

Over recent decades, the field of cellular senescence has attracted considerable attention
due to its association with aging, the development of age-related diseases and cancer …

Simple Summary Senescence is a form of cell cycle arrest induced by stresses such as DNA
damage and oncogenes and therefore constitutes a crucial barrier against cancer …

The senescence response is a potent tumor suppressor mechanism characterized by an
irreversible growth arrest in response to potentially oncogenic signals to prevent the …

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and
proliferation leading to the degeneration of cellular structure and function, has been …