Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-
coding products. Many transcripts are short lived due to their nuclear degradation by the …

The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate
targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein …

Controlling proper RNA pool for nuclear export is important for accurate gene expression.
ZFC3H1 is a key controller that not only facilitates nuclear exosomal degradation, but also …

Many long noncoding RNAs (lncRNAs) are unstable and rapidly degraded in the nucleus by
the nuclear exosome. An exosome adaptor complex called NEXT (nuclear exosome …

The RNA exosome is a conserved degradation machinery, which obtains full activity only
when associated with cofactors. The most prominent activator of the yeast nuclear exosome …

The exosome is a key RNA machine that functions in the degradation of unwanted RNA s.
Here, we found that significant fractions of precursors and mature forms of mRNA s and long …

The ribonucleolytic exosome complex is central for nuclear RNA degradation, primarily
targeting non-coding RNAs. Still, the nuclear exosome could have protein-coding (pc) gene …

Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+)
RNA is facilitated by the Poly (A) Tail eXosome Targeting (PAXT) connection. Besides its …

Degradation of transcripts in human nuclei is primarily facilitated by the RNA exosome. To
obtain substrate specificity, the exosome is aided by adaptors; in the nucleoplasm, those …

Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome,
which is regulated by accessory factors. However, the mechanism of exosome recruitment to …