Thyroid function alterations induced by amiodarone treatment (200-400 mg/day for 5
days/week) were studied in 50 patients with heart disease (age 34-75 years, mean age …

Amiodarone, an iodinated benzofuran derivative, was introduced in the 1960s as an
antianginal agent with coronary vasodilator properties. Later description of its antiaiThythmic …

Thyroid function was evaluated clinically and biochemically in 12 patients with ischaemic
heart disease receiving 200 mg oral amiodarone three times daily for periods up to 6 weeks …

The effects of amiodarone on thyroid function tests in 100 patients treated for 6 weeks to 8
years are reported. One patient became thyrotoxic and 10 developed latent or overt …

In order to evaluate the effects of amiodarone on thyroid function in chronically treated
patients, 43 consecutive patients, who had been taking a mean weekly dose of 1420±488 …

Amiodarone blocks the action of thyroid hormone by the inhibition of 5′-deiodinase which
reduces production of T 3 in peripheral tissues and possibly by blocking nuclear binding of T …

Amiodarone has been used in cardiology for more than 20 years as an anti-angina and anti-
arrhythmia agent. In the seventies, variations in thyroid hormone and TSH concentrations …

Serum thyroxine (T4), triiodothyronine (T3), resin uptake of T3 (RT3U), thyroid stimulating
hormone (TSH) and TSH response to thyrotropin releasing hormone (TRH) were measured …

Of a population of 400 patients treated with amiodarone, 97 underwent thyroid function
evaluation. Of these, 20 patients proved to be thyrotoxic and 16 hypothyroid. In thyrotoxic …

Plasma concentrations of T4, FT4, T3, rT3 and TBG, as well as of TSH before and after
stimulation with TRH were studied in 25 patients, who had been treated with amiodarone for …