The principal pathogenic event in Parkinson's disease is characterized by the
conformational change of α-synuclein, which form pathological aggregates of misfolded …

Formation and aggregation of misfolded proteins in the central nervous system (CNS) is a
key hallmark of several age-related neurodegenerative diseases, including Parkinson's …

The prion properties of alpha-synuclein, a key aggregating protein involved in the
pathogenesis of so-called synucleinopathies, including Parkinson's disease (PD), dementia …

In Parkinson's disease, intracellular α-synuclein inclusions form in neurons. We suggest that
prion-like behavior of α-synuclein is a key component in Parkinson's disease pathogenesis …

The discovery of alpha-synuclein's prion-like behaviors in mammals, as well as a non-
Mendelian type of inheritance, has led to a new concept in biology, the “prion hypothesis” of …

α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component
of Lewy bodies, but it is implicated in several cellular processes that are disrupted in …

Parkinson's disease is one of several neurodegenerative diseases associated with a
misfolded, aggregated and pathological protein. In Parkinson's disease this protein is alpha …

Background Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder
which affects widespread areas of the brainstem, basal ganglia and cerebral cortex. A …

Parkinson's disease (PD) is one of the synucleinopathies spectrum of disorders typified by
the presence of intraneuronal protein inclusions. It is primarily composed of misfolded and …

For more than a decade, the “prion-like” hypothesis for Parkinson's disease (PD) has
remained one of the most controversial topics in neurodegenerative disease research [21 …