Increasing evidence suggests that spinal microglia regulate pathological pain in males. In
this study, we investigated the effects of several microglial and astroglial modulators on …

Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by
activation in glial cells in various pain‐related regions within the central nervous system …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the
central nervous system. Dysregulation of microglia has been critically implicated in the …

Previous studies have shown that activation of p38 mitogen-activating kinase (MAPK) in
spinal microglia participates in the generation of inflammatory and neuropathic pain in …

Recent studies have suggested a sexually dimorphic role of spinal glial cells in the
maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used …

Microglia–neuron signalling in the spinal cord is a key mediator of mechanical allodynia
caused by peripheral nerve injury. We recently reported sex differences in microglia in pain …

Mounting evidence supports the hypothesis that spinal microglia modulate the development
and maintenance of some chronic pain states. Here we examined the role of spinal …

Neuropathic pain after spinal cord injury (SCI) is developed in about 80% of SCI patients
and there is no efficient therapeutic drug to alleviate SCI-induced neuropathic pain. Here we …

Substantial evidence has implicated microglia in neuropathic pain. After peripheral nerve
injury, microglia in the spinal cord proliferate and increase cell-surface expression of the …