Attenuation of ecstasy-induced neurotoxicity by N-acetylcysteine

S Soleimani Asl, B Saifi, A Sakhaie… - Metabolic brain …, 2015 - Springer
Abstract Exposure to 3, 4-methylenedioxymethamphetamine (MDMA) can lead to spatial
memory impairments and hippocampal cell death. Numerous evidence indicates that the …

Protective effects of N-acetylcysteine on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague–Dawley rats

S Soleimani Asl, K Mousavizedeh, B Pourheydar… - Metabolic brain …, 2013 - Springer
Abstract Exposure to 3, 4-methylenedioxymethamphetamine (MDMA) leads to spatial
memory impairment and hippocampal cell death. In the present study we have examined the …

Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine

G Fukami, K Hashimoto, K Koike, N Okamura… - Brain research, 2004 - Elsevier
Several lines of evidence suggest that oxidative stress may play a role in the behavioral
changes and neurotoxicity in rats after administration of methamphetamine (MAP). N-acetyl-l …

Neurochemical and neurotoxic effects of MDMA (ecstasy) and caffeine after chronic combined administration in mice

AM Górska, K Kamińska, A Wawrzczak-Bargieła… - Neurotoxicity …, 2018 - Springer
Abstract MDMA (3, 4-methylenedioxymethamphetamine) is a psychostimulant popular as a
recreational drug because of its effect on mood and social interactions. MDMA acts at …

N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells

X Zhang, A Banerjee, WA Banks, N Ercal - Brain research, 2009 - Elsevier
Oxidative stress plays an important role in neurodegenerative disorders such as Parkinson's
disease and Alzheimer's disease. Methamphetamine (METH) is an amphetamine analog …

N-Acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice

X Zhang, S Tobwala, N Ercal - Human & experimental …, 2012 - journals.sagepub.com
Methamphetamine (METH), a highly addictive drug used worldwide, induces oxidative
stress in various animal organs, especially the brain. This study evaluated oxidative damage …

[HTML][HTML] Ecstasy-induced caspase expression alters following ginger treatment

SS Asl, B Pourheydar, F Dabaghian… - Basic and Clinical …, 2013 - ncbi.nlm.nih.gov
Methods 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or
MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase …

Neurotoxicity of ecstasy metabolites in rat cortical neurons, and influence of hyperthermia

JP Capela, A Meisel, AR Abreu, PS Branco… - … of Pharmacology and …, 2006 - ASPET
3, 4-Methylenedioxymethamphetamine (MDMA or “Ecstasy”) is a widely abused,
psychoactive recreational drug. There is growing evidence that the MDMA neurotoxic profile …

Enzymatic–nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers …

I Riezzo, D Cerretani, C Fiore, S Bello… - Journal of …, 2010 - Wiley Online Library
Methylenedioxymethamphetamine (MDMA)‐induced neurotoxicity leads to the formation of
quinone metabolities and hydroxyl radicals and then to the production of reactive oxygen …

Treadmill exercise attenuates 3, 4‐methylenedioxymethamphetamine‐induced memory impairment through a decrease apoptosis in male rat hippocampus

A Gharebaghi, I Amiri, I Salehi… - Journal of …, 2017 - Wiley Online Library
methylenedioxymethamphetamine (MDMA) leads to apoptosis in the hippocampus with
consequent induction of learning and memory impairment. In this study, we have …