Cellular metabolism is not only essential for tumor cells to sustain their rapid growth and
proliferation, but also crucial to maintain T cell fitness and robust immunity. Dysregulated …

T cells play central roles in the anti-tumor immunity, whose activation and differentiation are
profoundly regulated by intrinsic metabolic reprogramming. Emerging evidence has …

T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that
distinct metabolic changes impact the activation and differentiation of T cells. Tailoring …

T cell metabolism has a central role in supporting and shaping immune responses and may
have a key role in antitumor immunity. T cell metabolism is normally held under tight …

With the rapid rise of immunotherapy for cancer treatment, attention has focused on gaining
a better understanding of T-cell biology in the tumor microenvironment. Elucidating the …

Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated
immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing …

There has been significant progress in utilizing our immune system against cancer, mainly
by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is …

Tumor microenvironment is characterized by a consistent reduction in oxygen and blood-
borne nutrients that significantly affects the metabolism of distinct cell subsets. Immune cells …

Mounting evidence has revealed that the therapeutic efficacy of immunotherapies is
restricted to a small portion of cancer patients. A deeper understanding of how metabolic …

Activation and maintenance of the T cell response occurs concurrently with metabolic
reprogramming. This ensures the T cell response is supported by sufficient energy and …