Objectives: We evaluated the respective influence of the causative pathogen and infection
site on hospital mortality from severe sepsis related to community-, hospital-, and intensive …

The goal of this study was to develop and validate clinical prediction rules for bacteremia
and subtypes of bacteremia in patients with sepsis syndrome. Thus, a prospective cohort …

BACKGROUND: The aim of this study was to identify risk factors for development of severe
sepsis or septic shock and to evaluate the clinical impact of severe sepsis on outcome in …

The impact of bloodstream infection (BSI) on admission to hospital on the outcome of
patients with community-acquired sepsis (CAS) admitted to intensive-care units (ICU) is …

Background The independent influence of blood culture testing and bloodstream infection
(BSI) on hospital mortality is unclear. Methods We included all adults treated in non …

For few biomarkers, recent study results demonstrate that well defined clinical protocols
have the potential to guide decisions about the individual risk stratification and treatment of …

Background Our current understanding of the pathophysiology and management of sepsis is
associated with a lack of progress in clinical trials, which partly reflects insufficient …

There is much enthusiasm and interest in sepsis biomarkers, particularly because sepsis is
a highly lethal condition, its diagnosis is challenging, and even simple treatment with …

Background Although 28% to 49% of severe sepsis hospitalizations have been described as
being “culture negative,” there are very limited data on the epidemiology and outcomes of …

Background Bacteria are the main pathogens that cause sepsis. The pathogenic
mechanisms of sepsis caused by gram-negative and gram-positive bacteria are completely …