[HTML][HTML] Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis

H Xia, V Bodempudi, A Benyumov, P Hergert… - The American journal of …, 2014 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the middle aged and elderly
with a prevalence of one million persons worldwide. The fibrosis spreads from affected …

Fibroblast phenotypes in pulmonary fibrosis

SH Phan - American journal of respiratory cell and molecular …, 2003 - search.proquest.com
A key feature of pulmonary fibrosis is the presence of fibroblasts at sites of active fibrosis. In
fact, the presence of a distinct lesion, termed a" fibroblastic focus," composed of fibroblasts …

Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis

S Wang, W Rao, A Hoffman, J Lin, J Li, T Lin… - Science translational …, 2023 - science.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …

Heterogeneity of fibroblasts and myofibroblasts in pulmonary fibrosis

DM Habiel, CM Hogaboam - Current pathobiology reports, 2017 - Springer
Abstract Purpose of Review Idiopathic pulmonary fibrosis (IPF) is the most common form of
interstitial lung disease of unknown etiopathogenesis with mean survival of 3–5 years and …

Origins of pathological myofibroblasts in lung fibrosis: insights from lineage tracing mouse models in the single-cell RNA sequencing era

M Homps-Legrand, B Crestani… - American Journal of …, 2023 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a rare interstitial lung disease with a poor prognosis.
Chronic microinjuries, mainly caused by environmental factors to an aging alveolar …

Two-way conversion between lipogenic and myogenic fibroblastic phenotypes marks the progression and resolution of lung fibrosis

E El Agha, A Moiseenko, V Kheirollahi, S De Langhe… - Cell stem cell, 2017 - cell.com
Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with
unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality …

Defining the activated fibroblast population in lung fibrosis using single-cell sequencing

R Peyser, S MacDonnell, Y Gao, L Cheng… - American journal of …, 2019 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …

IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity

L Yang, J Herrera, A Gilbertsen, H Xia… - … of Physiology-Lung …, 2018 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease, but the
mechanisms driving progression remain incompletely defined. We previously reported that …

The quest for the initial lesion in idiopathic pulmonary fibrosis: gene expression differences in IPF fibroblasts

O Eickelberg, GJ Laurent - American journal of respiratory cell and …, 2010 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder due to its unresolved
pathogenesis and limited responsiveness to currently available therapies. It is characterized …

Idiopathic pulmonary fibrosis is associated with endothelial to mesenchymal transition

D Nataraj, A Ernst, R Kalluri - American journal of respiratory cell …, 2010 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) affects over 500,000 people in the United States and
Europe alone. The disease is characterized by progressive obliteration of normal alveolar …