Personalizing ocrelizumab treatment in Multiple Sclerosis: What can we learn from Sars-Cov2 pandemic?

F Tazza, C Lapucci, M Cellerino, G Boffa, G Novi… - Journal of the …, 2021 - Elsevier
Abstract During SARS-CoV-2 pandemic, we adopted a personalized delayed protocol for
ocrelizumab infusions in Relapsing Remitting Multiple Sclerosis (RRMS) patients according …

Influence of delaying ocrelizumab dosing in multiple sclerosis due to COVID-19 pandemics on clinical and laboratory effectiveness

B Barun, T Gabelić, I Adamec, A Babić, H Lalić… - Multiple Sclerosis and …, 2021 - Elsevier
Objective To evaluate clinical and laboratory effects of delaying ocrelizumab infusions
during the COVID-19 pandemics in people with multiple sclerosis (pwMS). Methods We …

Humoral and T-cell response to SARS-CoV-2 vaccination in patients with multiple sclerosis treated with ocrelizumab

L Brill, A Rechtman, O Zveik, N Haham… - JAMA …, 2021 - jamanetwork.com
Importance B-cell–depleting therapies may affect the development of a protective immune
response following vaccination. Understanding the ability to develop vaccine-specific …

Therapeutic recommendations and seasonal influenza vaccine for multiple sclerosis patients in treatment with ocrelizumab: an expert consensus

M Filippi, R Capra, D Centonze, C Gasperini, F Patti… - Journal of …, 2021 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus
disease 2019 (COVID-19) has killed hundreds of thousands of humans in a global …

Personalized B-cell tailored dosing of ocrelizumab in patients with multiple sclerosis during the COVID-19 pandemic

ZYGJ van Lierop, AA Toorop… - Multiple Sclerosis …, 2022 - journals.sagepub.com
In this observational study, 159 patients with multiple sclerosis received personalized dosing
of ocrelizumab incentivized by the COVID-19 pandemic. Re-dosing was scheduled when …

Evidence of extensive cellular immune response after SARS-CoV-2 vaccination in ocrelizumab-treated patients with multiple sclerosis

M Pompsch, N Fisenkci, PA Horn, M Kraemer… - … Research and Practice, 2021 - Springer
Background Patients with multiple sclerosis receiving ocrelizumab-treatment are in
desperate need of a protection against SARS-CoV-2 infection. Methods In this study …

Ocrelizumab extended‐interval dosing in multiple sclerosis during SARS‐CoV‐2 pandemic: a real‐world experience

S Guerrieri, C Bucca, A Nozzolillo… - European Journal of …, 2023 - Wiley Online Library
Background and purpose During the COVID‐19 pandemic, ocrelizumab administration was
frequently postponed because of a lack of safety information and to favour vaccination. The …

[HTML][HTML] Humoral and T-cell responses to SARS-CoV-2 vaccination in multiple sclerosis patients treated with ocrelizumab

JD Katz, AJ Bouley, RM Jungquist, EA Douglas… - Multiple Sclerosis and …, 2022 - Elsevier
Background The COVID-19 epidemic raises important questions about the efficacy of
vaccines for people treated with ocrelizumab, an anti-CD20 therapy. Ocrelizumab has been …

Ocrelizumab Concentration Is a Good Predictor of SARS‐CoV‐2 Vaccination Response in Patients with Multiple Sclerosis

ZLE van Kempen, L Hogenboom, AA Toorop… - Annals of …, 2023 - Wiley Online Library
Ocrelizumab, an anti‐CD20 monoclonal antibody, counteracts induction of humoral immune
responses after severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) …

Ocrelizumab extended interval dosing in multiple sclerosis in times of COVID-19

L Rolfes, M Pawlitzki, S Pfeuffer, C Nelke… - Neurology …, 2021 - AAN Enterprises
Objective To evaluate the clinical consequences of extended interval dosing (EID) of
ocrelizumab in relapsing-remitting multiple sclerosis (RRMS) during the coronavirus disease …