Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders

S Kim, MJ Webster - Molecular psychiatry, 2011 - nature.com
Cytoarchitectural abnormalities have been described in the prefrontal cortex (PFC) of
subjects with psychiatric disorders. We explored the possible genetic causalities that may …

Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders

S Kim, MJ Webster - Molecular psychiatry, 2010 - nature.com
Cytoarchitectural abnormalities have been described in the prefrontal cortex of subjects with
schizophrenia, bipolar disorder and depression. However, little is known about the gene …

[HTML][HTML] The overlapping genetic architecture of psychiatric disorders and cortical brain structure

Z Sha, V Warrier, RAI Bethlehem, LM Schultz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Both psychiatric vulnerability and cortical structure are shaped by the cumulative effect of
common genetic variants across the genome. However, the shared genetic underpinnings …

The general impact of haploinsufficiency on brain connectivity underlies the pleiotropic effect of neuropsychiatric CNVs

C Moreau, G Huguet, S Urchs… - Biological …, 2021 - biologicalpsychiatryjournal.com
Background Resting-state functional MRI studies have provided critical insight into brain
networks involved in neuropsychiatric conditions (NPs) but only a few studies have …

Cross-disorder analysis of shared genetic components between cortical structures and major psychiatric disorders

Z Li, D Li, Y He, K Wang, X Ma, X Chen - Schizophrenia Bulletin, 2022 - academic.oup.com
Abstract Background and Hypothesis Although large-scale neuroimaging studies have
demonstrated similar patterns of structural brain abnormalities across major psychiatric …

Overlap in genetic risk for cross-disorder vulnerability to mental disorders and genetic risk for altered subcortical brain volumes

M Campbell, N Jahanshad, M Mufford, KW Choi… - Journal of Affective …, 2021 - Elsevier
Background There have been considerable recent advances in understanding the genetic
architecture of psychiatric disorders as well as the underlying neurocircuitry. However, there …

[HTML][HTML] Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations

T Wang, X Zhang, A Li, M Zhu, S Liu, W Qin, J Li… - NeuroImage: Clinical, 2017 - Elsevier
Major psychiatric disorders, including attention deficit hyperactivity disorder (ADHD), autism
(AUT), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ), are …

A genome-wide association study suggests novel loci associated with a schizophrenia-related brain-based phenotype

J Hass, E Walton, H Kirsten, J Liu, L Priebe, C Wolf… - PLoS …, 2013 - journals.plos.org
Patients with schizophrenia and their siblings typically show subtle changes of brain
structures, such as a reduction of hippocampal volume. Hippocampal volume is heritable …

Effects of eight neuropsychiatric copy number variants on human brain structure

C Modenato, K Kumar, C Moreau… - Translational …, 2021 - nature.com
Many copy number variants (CNVs) confer risk for the same range of neurodevelopmental
symptoms and psychiatric conditions including autism and schizophrenia. Yet, to date …

Psychiatric polygenic risk associates with cortical morphology and functional organization in aging

A Lee, M Shen, A Qiu - Translational Psychiatry, 2017 - nature.com
Common brain abnormalities in cortical morphology and functional organization are
observed in psychiatric disorders and aging, reflecting shared genetic influences. This …