There is ample evidence that subtle changes in the early environment, not restricted to the
fetal period but expanded to the plastic phase of early development, influence adulthood …

For decades it has been postulated that the period in utero may be critical in modifying the
risk of adult-onset disease, although only recently has epigenetic change emerged as the …

Several lines of evidence point to the early origin of adult onset disease. A key question is:
what are the mechanisms that mediate the effects of the early environment on our health …

We all know our environment affects our risk of disease. But importantly, the health
consequences of environmental exposures depend not only on their severity but also on …

There is now considerable evidence that elements of the heritable or familial component of
disease susceptibility are transmitted by nongenomic means, and that environmental …

Abstract The Developmental Origins of Health and Disease hypothesis describes how early
life environmental factors influence development in a way that impacts later health and …

Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

In the spring of 1998 my co-editor, colleague and friend, Randy Jirtle, approached me at a
scientific meeting in San Diego, CA to discuss something that clearly had him excited …

Epidemiological and experimental studies have shown that the peri-conception period,
pregnancy, and infancy are windows of particular sensibility to environmental clues which …

The importance of developmental factors in influencing the risk of later-life disease has a
strong evidence base derived from multiple epidemiological, clinical and experimental …