Recent genomic research increases our understanding of the causes of complex diseases
and strengthens the evidence that many complex diseases, even those with late age of …

Trevor K. Archer Paul A. Wade the cell cycle, in response to biologic signaling systems, and
with environmental changes. Deciphering how the epigenome responds to environmental …

The hypothesis that environmental factors alter somatically heritable epigenetic marks and
change long-term patterns of gene expression is an exciting possibility in human disease …

Increasing epidemiological evidence suggests that maternal nutrition and environmental
exposure early in development play an important role in susceptibility to disease in later life …

The greatest burden of ill-health for adults in most societies relates to disorders of the
cardiovascular system and to cancers [1]. These diseases are caused by lifestyle choices in …

Abstract The literature about Developmental Origins of Health and Disease (DOHaD)
studies is considerably growing. Maternal and paternal environment, during all the …

Environmental insults, such as exposure to toxicants or nutritional abnormalities, can lead to
epigenetic changes that are in turn related to increased susceptibility to disease. The focus …

The phenotype of an individual is the result of complex interactions between genotype,
epigenome and current, past and ancestral environment, leading to lifelong remodelling of …

Traditionally it has been widely accepted that our genes together with adult lifestyle factors
determine our risk of developing non-communicable diseases such as type 2 diabetes …

On Tuesday, November 2, 2005 over 450 scientists representing 14 nations converged on
the Washington Duke Inn, Durham, NC, USA to discuss, learn and exchange information on …