Synthesis of novel pyrido[3,4‐d]pyrimidine‐thiazolidione‐1,2,4‐oxadiazoles as potent EGFR targeting anticancer agents

BD Varaprasadu, SB Haridasyam… - Journal of Heterocyclic … - Wiley Online Library
In this study, we designed and synthesized a number of novel pyrido [3, 4‐d] pyrimidine‐
thiazolidine‐1, 2, 4‐oxadiazole derivatives and investigated them in vitro for their inhibitory …

Benzoxazole derivatives as new generation of anti-breast cancer agents

AMME Omar, OM AboulWafa, MS El-Shoukrofy… - Bioorganic …, 2020 - Elsevier
New 2-substituted benzoxazole derivatives were synthesized and screened for their in vitro
anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d …

Synthesis, biological evaluation, and molecular docking of new benzimidazole-1, 2, 3-triazole hybrids as antibacterial and antitumor agents

S Ahmed Saleh Alzahrani, S Nazreen… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A new series of benzimidazole-1, 2, 3-triazole hybrids have been successfully accomplished
by the Click chemistry of different aromatic azides and propargylated benzimidazole (4). The …

One-Pot Synthesis of Some New Phthalazine-Piperazine-1, 2, 4-Oxadiazole Hybrids: Anticancer Evaluation, Molecular Docking and ADMET Studies

R Samala, SK Nukala, NS Thirukovela… - Polycyclic Aromatic …, 2023 - Taylor & Francis
We herein, described the synthesis of some new phthalazine-piperazine-1, 2, 4-oxadiazole
hybrids (4a–n). All the synthesized compounds were evaluated for their in vitro anti-cancer …

Design, synthesis and molecular docking studies of new Quinoxaline-linked-1, 2, 4-triazole-Sulfonamide hybrids as Anti-proliferative agents

MR Nallapu, R Vadluri, J Arasan - Chemical Biology Letters, 2022 - pubs.thesciencein.org
A new series of quinoxaline linked 1, 2, 4-triazole sulfonamide derivatives were designed
and efficiently synthesized. All compounds were characterized by their IR, 1HNMR …

Synthesis and in vitro anticancer evaluation of some fused indazoles, quinazolines and quinolines as potential EGFR inhibitors

EA Abdelsalam, WA Zaghary, KM Amin… - Bioorganic …, 2019 - Elsevier
Abstract derivatives of benzo [g] indazole 5a, b, benzo [h] quinazoline 7, 12a-c, 13a-c and
15a-c and benzo [h] quinoline 17a-c and 19a-c were synthesized from 6-methoxy-3, 4 …

Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents

SR Bandi, R Kapavarapu, R Palabindela… - Journal of Molecular …, 2023 - Elsevier
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Synthesis, biological evaluation, and molecular modeling studies of acetophenones‐tethered 1, 2, 4‐triazoles and their oximes as epidermal growth factor receptor …

HAAA El‐Wahab, AM Ali… - Chemical Biology & …, 2022 - Wiley Online Library
Abstract A series of 5‐(4‐pyridyl)‐1, 2, 4‐triazoles hybrids with acetophenones and their
oxime derivatives was rationally designed and synthesized as epidermal growth factor …

Coumarin-Piperazine Tethered 1, 2, 3-Triazoles: EGFR Targeting Anti-Breast Cancer Evaluation and Molecular Docking Studies

KH Gangadhar, V Benarjee… - Polycyclic Aromatic …, 2023 - Taylor & Francis
We synthesized a new series of coumarin-piperazine 1, 2, 3-triazole hybrids (7a–7n) and
screened for their in vitro anti-breast cancer activity against MCF-7, MDA-MB-468, and MDA …

Novel 1, 2, 4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

HAM El-Sherief, BGM Youssif, SNA Bukhari… - Bioorganic …, 2018 - Elsevier
A series of novel compounds carrying 1, 2, 4-triazole scaffold was synthesized and
evaluated for their anticancer activity against a panel of cancer cell lines using MTT assay …