Design, synthesis and antiproliferative evaluation of novel 1, 2, 4-triazole/schiff base hybrids with EGFR and B-RAF inhibitory activities
HAM El-Sherief, BGM Youssif… - Anti-Cancer Agents …, 2019 - ingentaconnect.com
Background: 1, 2, 4-triazoles possess a broad spectrum of biological activities such as
analgesic, antimicrobial, antitubercular, anti-inflammatory and antineoplastic activities. This …
analgesic, antimicrobial, antitubercular, anti-inflammatory and antineoplastic activities. This …
Design, synthesis and anticancer activity of sulfonamide derivatives of 1, 2, 3-triazole-indoles
MS Rani, K Krishnadevi, M Rajeswari… - Chemical Data …, 2023 - Elsevier
A new series of sulfonamide derivatives of 1, 2, 3-triazole-indole (12a–j) were designed and
prepared. All compounds were characterized by 1 HNMR, 13 CNMR and mass spectral …
prepared. All compounds were characterized by 1 HNMR, 13 CNMR and mass spectral …
Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents
SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
New molecular hybrids containing benzimidazole, thiazolidine-2, 4-dione and 1, 2, 4-oxadiazole as EGFR directing cytotoxic agents
B Saritha, BBV Sailaja - Tetrahedron, 2022 - Elsevier
Herein, we, synthesized some new molecular hybrids (7a-o) having benzimidazole,
thiazolidine-2, 4-dione and 1, 2, 4-oxadiazole scaffolds from the commercially available 1 …
thiazolidine-2, 4-dione and 1, 2, 4-oxadiazole scaffolds from the commercially available 1 …
Synthesis, Molecular Docking Study, and Anticancer Activity of 7-Azaindole-1,2,3-triazol Bearing N-Benzamide Derivatives
Y Wang, R Chen, Y Hu, S Jiao, Z Zou - Russian Journal of General …, 2022 - Springer
In this study, a novel series of 7-azaindole-1, 2, 3-triazole bearing N-benzamide derivatives
3a–3r were synthesized and fully characterized by 1H NMR, 13C NMR, and MS. The …
3a–3r were synthesized and fully characterized by 1H NMR, 13C NMR, and MS. The …
Design, synthesis, and antiproliferative activities of novel substitutedhydrazone/triazolo-linked quinazoline derivatives
A series of novel hydrazonoquinazolines and triazoloquinazolines analogues of Erlotinib
were synthesized and evaluated for their antiproliferative as well as EGFR kinase inhibitory …
were synthesized and evaluated for their antiproliferative as well as EGFR kinase inhibitory …
Computational design, synthesis, and assessment of 3-(4-(4-(1, 3, 4-oxadiazol-2-yl)-1 H-imidazol-2-yl) phenyl)-1, 2, 4-oxadiazole derivatives as effective epidermal …
NR Khedkar, M Sindkhedkar, A Joseph - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
The epidermal growth factor receptor (EGFR) enzyme plays a critical role in governing the
cell cycle, positioning it as a promising target for the development of anticancer drugs. In this …
cell cycle, positioning it as a promising target for the development of anticancer drugs. In this …
Design and synthesis of some new imidazole-morpholine-1, 2, 4-oxadiazole hybrids as EGFR targeting in vitro anti-breast cancer agents
P kumar Kannekanti, SK Nukala, S Bandari… - Journal of Molecular …, 2024 - Elsevier
Herein, we synthesized some new imidazole-moprholine-1, 2, 4-oxadiazoles (7a-7o) and
characterized their structures using 1 H NMR, 13 C NMR, ESI-mass and CHN analyses …
characterized their structures using 1 H NMR, 13 C NMR, ESI-mass and CHN analyses …
Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1, 2, 3-triazole fragment that mimic quinazoline epidermal growth factor receptor …
N Rezki, MA Almehmadi, S Ihmaid, AM Shehata… - Bioorganic …, 2020 - Elsevier
A series of benzothiazole/isatin linked to 1, 2, 3-triazole moiety and terminal sulpha drugs 5a-
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …
Design, synthesis, and apoptotic antiproliferative action of new 1, 2, 3-triazole/1, 2, 4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors
Abstract A novel series of 1, 2, 3-triazole/1, 2, 4-oxadiazole hybrids (7a–o) was developed
as dual inhibitors of EGFR/VEGFR-2. Compounds 7a–o were evaluated as antiproliferative …
as dual inhibitors of EGFR/VEGFR-2. Compounds 7a–o were evaluated as antiproliferative …