Functional retroviral integrase protein is thought to be essential for productive viral
replication. Yet, previous studies differed on the extent to which integrase mutant viruses …

The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN) is essential for
integration of the viral DNA into host cell chromosomes. Since IN is expressed and …

Retrovirus integration requires at least two viral components, one of the three retroviral
enzymes, integrase, and cis-acting sequences at the ends of the retroviral DNA termini U3 …

Retroviral integrases (INs) function in the context of preintegration complexes (PICs). Two
conserved Lys residues in the N-terminal domain of human immunodeficiency virus type 1 …

ABSTRACT Integrase interactor 1 (INI1)/hSNF5 is a host factor that directly interacts with
human immunodeficiency virus type 1 (HIV-1) integrase and is incorporated into HIV-1 …

Sequence comparisons of the integrase (IN) proteins from different retroviruses have
identified several highly conserved residues. We have introduced mutations at 16 of these …

Antiretroviral drugs to prevent integration of the HIV viral genome into chromosomes are
undergoing clinical trials, yet they have been developed with an imperfect understanding of …

The integration of a DNA copy of the retroviral RNA genome into the host cell genome is
essential for viral replication. The virion-associated integrase protein, encoded by the 3'end …

The human immunodeficiency virus (HIV) integrase protein (IN) catalyzes two reactions
required to integrate HIV DNA into the human genome: 3′ processing of the viral DNA ends …

Previously, we reported that an HIV-1 variant containing Met-to-Ile change at codon 50 and
Val-to-Ile mutation at codon 151 of integrase (IN), HIV (IN: M50I/V151I), was an impaired …