Parallel bioassay on smooth muscle preparations demonstrated that: all TKs having a
neutral or basic residue at position 7 from the C-terminus show a clear-cut preference for the …

Besides Substance P (SP)[I], two tachykinins have been isolated from the brain and the
spinal cord of mammals, ie Neurokinin A (NKA, also named Substance K and Neuromedin …

The possible existence of NK-2 receptor subtypes in peripheral smooth muscle preparations
from rabbit and hamster was investigated by studying the effect of neurokinin A, the selective …

Recent evidence indicates that the tachykinin NK-2 receptor is heterogenous
(subtypes/species variants) and the existence of NK-2A (or 'non-classical') and NK-2B (or …

The tachykinins, substance P, neurokinin A and neurokinin B, are a family of neuropeptides
widely distributed in the mammalian central and peripheral nervous system. In the …

Three types of binding sites for the mammalian tachykinins, ie Substance P (SP) Neurokinin
A (NKA) and Neurokinin B (NKB), have been found in both the central and peripheral …

The heterogeneity of tachykinin NK2 receptor subtypes was examined in five tissues from
the rat, using binding and functional techniques. Initial experiments with the selective …

Tachykinins are a family of peptides that share the common C-terminal sequence, Phe-X-Gly-
Leu-Met-NH,. In mammals, at least three different tachykinins, namely, substance P (SP) …

The mammalian tachykinin peptides-substance P (SP), neurokinin A (NKA), and neurokinin
B (NKB)-have been postulated to preferentially bind to and activate distinct types of …

Publisher Summary This chapter discusses the technical aspects of the methods related to
treatment of tachykinin (TK) receptors. TKs represent a family of structurally related peptides …