Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …

Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a
driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately …

Chromosomal instability (CIN) is a hallmark of human neoplasms. Despite its widespread
prevalence, knowledge of the mechanisms and contributions of CIN in cancer has been …

Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of
mutations conferring aggressive or drug-resistant phenotypes during cancer evolution …

Two prominent features of cancer cells are abnormal numbers of chromosomes
(aneuploidy) and large-scale structural rearrangements of chromosomes. These …

Chromosomal instability (CIN)—which is a high rate of loss or gain of whole or parts of
chromosomes—is a characteristic of most human cancers and a cause of tumour aneuploidy …

Simple Summary Chromosome instability (CIN) is characterized by an increased
accumulation of numerical and structural changes in chromosomes and is a common feature …

Cancer is a devastating disease that claims over 8 million lives each year. Understanding
the molecular etiology of the disease is critical to identify and develop new therapeutic …

Human cancers harbor great numbers of genomic alterations. One of the most common
alterations is aneuploidy, an imbalance at the chromosome level. Some aneuploid cancer …