Single-cell sequencing technologies can be used to detect the genome, transcriptome and
other multi-omics of single cells. They can show the differences and evolutionary …

Unlike population-level approaches, single-cell RNA sequencing enables transcriptomic
analysis of an individual cell. Through the combination of high-throughput sequencing and …

Bulk genomic analyses and expression profiling of clinical specimens have shaped much of
our understanding of cancer in patients. However, human tumors are intricate ecosystems …

Single cell sequencing (SCS) has become a new approach to study biological
heterogeneity. The advancement in technologies for single cell isolation, amplification of …

Genetic changes and environmental differences result in cellular heterogeneity among
cancer cells within the same tumor, thereby complicating treatment outcomes. Recent …

Genomic studies have provided key insights into how cancers develop, evolve, metastasize
and respond to treatment. Cancers result from an interplay between mutation, selection and …

Unlike bulk-cell analysis, single-cell approaches have the advantage of assessing cellular
heterogeneity that governs key aspects of tumor biology. Yet, their applications to circulating …

Circulating tumor cells are tumor cells with high vitality and high metastatic potential that
invade and shed into the peripheral blood from primary solid tumors or metastatic foci. Due …

Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

Here, we review single-cell sequencing techniques for individual and multiomics profiling in
single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic …