Increased bone resorption by osteoclasts after estrogen deficiency is the main cause of
postmenopausal osteoporosis. TET2 (tet methylcytosine dioxygenase 2) is a DNA …

The development of osteoporosis is often accompanied by autophagy disturbance, which
also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs) …

The aim of this study is to evaluate the effect of transient receptor potential vanilloid 4
(TRPV4) on osteoclast differentiation and osteoporosis, and to investigate the underlying …

ABSTRACT A reduction in trabecular bone mass is often associated with an increase in
marrow fat in osteoporotic bones. The molecular mechanisms underlying this inverse …

TREM2 is an immunoreceptor expressed on osteoclasts (OC) and microglia that transmits
intracellular signals through the adaptor DAP12. Individuals with genetic mutations …

Background Postmenopausal bone loss, mainly caused by excessive bone resorption
mediated by osteoclasts, has become a global public health burden. Metformin, a …

Cadmium (Cd) is one of worldwide environmental pollutants that causes bone homeostasis,
which depends on the resorption of bones by osteoclasts and formation of bones by the …

Steroid‐associated osteonecrosis (SAON) is one of the common complications of clinical
glucocorticoid (GC) administration, with osteocyte apoptosis appearing as the primary …

Abstract Background The 5 hydroxymethylation (5hmC) mark and TET DNA dioxygenases
play a pivotal role in embryonic stem cell differentiation and animal development. However …

Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-
forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that …