Underlying mechanisms of pituitary–thyroid axis function disruption by chronic iodine excess in rats

J Calil-Silveira, C Serrano-Nascimento, RC Laconca… - Thyroid, 2016 - liebertpub.com
Background: Iodine is essential for thyroid hormone synthesis and is an important regulator
of thyroid function. Chronic iodine deficiency leads to hypothyroidism, but iodine excess also …

Long-term effects of high iodine intake: inhibition of thyroid iodine uptake and organification in Wistar rats

N Man, HX Guan, ZY Shan, YS Li, CL Fan… - Zhonghua yi xue za …, 2006 - europepmc.org
Objective To investigate the effects of chronic iodine excess on thyroid function, thyroid
peroxidase (TPO) activity, and expression of sodium-iodide symporter (NIS). Methods 500 …

The impact of iodine excess on thyroid hormone biosynthesis and metabolism in rats

K Wang, YN Sun, JY Liu, L Zhang, Y Ye, LX Lin… - Biological trace element …, 2009 - Springer
Thyroid function ultimately depends on appropriate iodine supply to the gland. There is a
complex series of checks and balances that the thyroid uses to control the orderly utilization …

Effect of chronic excess iodine intake on thyroid function and oxidative stress in hypothyroid rats

AEAM Hussein, AM Abbas, GA El Wakil… - Canadian journal of …, 2012 - cdnsciencepub.com
Our objective was to investigate the effects of chronic excess iodine intake on thyroid
functions and thyroid oxidative stress state in hypothyroid rats. Sixty rats were divided into …

[HTML][HTML] Effects of increased iodine intake on thyroid disorders

X Sun, Z Shan, W Teng - Endocrinology and metabolism, 2014 - ncbi.nlm.nih.gov
Iodine is a micronutrient essential for the production of thyroid hormones. Iodine deficiency
is the most common cause of preventable mental impairment worldwide. Universal salt …

Nitric oxide is involved in the hypothyroidism with significant morphology changes in female Wistar rats induced by chronic exposure to high water iodine from …

S Rong, Y Gao, Y Yang, H Shao, AP Okekunle, C Lv… - Chemosphere, 2018 - Elsevier
Epidemiological studies indicated that chronic exposure to high water iodine is associated
with primary hypothyroidism (PH) and subclinical hypothyroidism (SCH). However, the …

Effects of iodine excess on serum thyrotropin-releasing hormone levels and type 2 deiodinase in the hypothalamus of Wistar rats

Y Sun, X Du, Z Shan, W Teng, Y Jiang - British Journal of Nutrition, 2022 - cambridge.org
Iodine is an important element in thyroid hormone biosynthesis. Thyroid function is regulated
by the hypothalamic–pituitary–thyroid axis. Excessive iodine leads to elevated thyroid …

Effect of mild and moderate excessive iodine supplementation on thyroid function and morphology in non-iodine deficiency rat model

TS Gao, FN Hu, WP Teng - Zhonghua nei ke za zhi, 2003 - europepmc.org
OBJECTIVE: To study the effect of moderate and mild iodine excess on thyroid function and
morphology in non iodine deficiency Wistar rats. METHODS: Serum thyroid-stimulating …

Maternal exposure to iodine excess throughout pregnancy and lactation induces hypothyroidism in adult male rat offspring

C Serrano-Nascimento, RB Salgueiro, T Pantaleão… - Scientific Reports, 2017 - nature.com
This study aimed to investigate the consequences of maternal exposure to iodine excess (IE;
0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis …

Induction of goitrous hypothyroidism by dietary iodide in SJL mice

HS Li, G Carayanniotis - Endocrinology, 2007 - academic.oup.com
Prolonged intake of large amounts of iodide has been reported to increase the incidence of
goiter and/or hypothyroidism in humans as well as animals prone to spontaneous …