Substrate-specific degradation is a key feature of the ubiquitin proteasome system.
Substrate specificity is typically directed by the E3 or ubiquitin ligase; such specificity can be …

NEDD8 is a ubiquitin (Ub)-like protein. Here we report a novel ubiquitinylation-related
pathway for modification by NEDD8. NEDD8 was activated by an E1 (Ub-activating enzyme) …

Cullin-RING ubiquitin ligases (CRLs) represent the largest family of E3 ubiquitin ligases that
control most if not all cellular processes. In CUL3-based CRLs, the substrate specificity is …

Abstract Cullin RING E3 ligases (CRLs) ubiquitylate hundreds of important cellular
substrates. Here we have assembled and purified the Ankyrin repeat and SOCS Box protein …

Ubiquitin (Ub)-conjugating enzymes and Ub ligases control protein degradation and
regulate many cellular processes in eukaryotes. Cellular inhibitor of apoptosis protein-1 …

The COP9 signalosome (CSN) is known to bind cullin-RING ubiquitin ligases (CRLs) and to
promote their activity in vivo,,. The mechanism of this stimulation has remained enigmatic …

The U box is a domain of∼ 70 amino acids that is present in proteins from yeast to humans.
The prototype U box protein, yeast Ufd2, was identified as a ubiquitin chain assembly factor …

Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2,
and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs) …

The cullin4A-RING E3 ubiquitin ligase (CRL4) is a multisubunit protein complex, comprising
cullin4A (CUL4), RING H2 finger protein (RBX1), and DNA damage-binding protein 1 …

Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of …