Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely …

BJ Wouters, B Löwenberg… - Blood, The Journal …, 2009 - ashpublications.org
Mutations in CCAAT/enhancer binding protein α (CEBPA) are seen in 5% to 14% of acute
myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most …

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further …

E Taskesen, L Bullinger, A Corbacioglu… - Blood, The Journal …, 2011 - ashpublications.org
We evaluated concurrent gene mutations, clinical outcome, and gene expression signatures
of CCAAT/enhancer binding protein alpha (CEBPA) double mutations (CEBPA dm) versus …

[HTML][HTML] CEBPA–double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features

F Mannelli, V Ponziani, S Bencini, MI Bonetti… - …, 2017 - ncbi.nlm.nih.gov
Mutations in CCAAT/enhancer binding protein α (CEBPA) occur in 5–10% of cases of acute
myeloid leukemia. CEBPA-double-mutated cases usually bear biallelic N-and C-terminal …

Prognostic impact of CEBPA bZIP domain mutation in acute myeloid leukemia

S Wakita, M Sakaguchi, I Oh, S Kako, T Toya… - Blood …, 2022 - ashpublications.org
Mutations of CCAAT/enhancer–binding protein alpha (CEBPA mu) are found in 10% to 15%
of de novo acute myeloid leukemia (AML) cases. Double-mutated CEBPA (CEBPA dm) is …

Somatic CEBPA Mutations Are a Frequent Second Event in Families With Germline CEBPA Mutations and Familial Acute Myeloid Leukemia

T Pabst, M Eyholzer, S Haefliger, J Schardt… - Journal of Clinical …, 2008 - ascopubs.org
Purpose The transcription factor CCAAT/enhancer binding protein-α (CEBPA) is crucial for
normal myeloid differentiation. Mutations in the CEBPA gene are found in subsets of patients …

CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome

F Taube, JA Georgi, M Kramer, S Stasik… - Blood, The Journal …, 2022 - ashpublications.org
Biallelic mutations of the CEBPA gene (CEBPA bi) define a distinct entity associated with
favorable prognosis; however, the role of monoallelic mutations (CEBPA sm) is poorly …

The role of different genetic subtypes of CEBPA mutated AML

A Fasan, C Haferlach, T Alpermann, S Jeromin… - Leukemia, 2014 - nature.com
The prognostic impact of mutations in the CCAAT/enhancer binding protein α (CEBPA) gene
was evaluated in the context of concomitant molecular mutations and cytogenetic …

Prognostic Significance of, and Gene and MicroRNA Expression Signatures Associated With, CEBPA Mutations in Cytogenetically Normal Acute Myeloid Leukemia …

G Marcucci, K Maharry, MD Radmacher… - Journal of clinical …, 2008 - ascopubs.org
Purpose To evaluate the prognostic significance of CEBPA mutations in the context of
established molecular markers in cytogenetically normal (CN) acute myeloid leukemia …

The favorable impact of CEBPA mutations in patients with acute myeloid leukemia is only observed in the absence of associated cytogenetic abnormalities and FLT3 …

A Renneville, N Boissel, N Gachard… - Blood, The Journal …, 2009 - ashpublications.org
Mutations of the CCAAT/enhancer binding protein alpha (CEBPA) gene have been
associated with a favorable outcome in patients with acute myeloid leukemia (AML), but …

[PDF][PDF] Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML

SBVW Van Doorn, C Erpelinck, J Meijer… - Hematol J, 2003 - academia.edu
The CCAAT/enhancer binding protein a is an essential transcription factor for granulocytic
differentiation. Recent studies reported N-and C-terminal CEBPA mutations in approximately …