Antidiabetic, antioxidant and cytotoxicity activities of ortho-and para-substituted Schiff bases derived from metformin hydrochloride: Validation by molecular docking …

I Al-Qadsy, WS Saeed, AB Al-Odayni, A Alrabie… - Open …, 2023 - degruyter.com
This work evaluates the in vitro antioxidant and antidiabetic activities of two metformin
hydrochloride-based Schiff bases. Moreover, the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl …

Antioxidant and antidiabetic potentials of methoxy-substituted Schiff bases using in vitro, in vivo, and molecular simulation approaches

M Kashif, S Naz, M Zahoor, SWA Shah, J Uddin… - Open …, 2024 - degruyter.com
The current study attempted to synthesize methoxy-substituted Schiff's bases, namely MK1
and MK2, and evaluate their antidiabetic effects using in vitro, in vivo, and molecular docking …

Antidiabetes and antioxidant potential of Schiff bases derived from 2-naphthaldehye and substituted aromatic amines: Synthesis, crystal structure, Hirshfeld surface …

SD Oladipo, RC Luckay, KA Olofinsan, VA Obakachi… - Heliyon, 2024 - cell.com
Three Schiff bases were synthesised by the condensation reaction between 2-
napthaldehyde and aromatic amines to afford (E)-N-mesityl-1-(naphthalen-2-yl) …

Synthesis and Therapeutic Potential of selected Schiff Bases: In vitro Antibacterial, Antioxidant, Antidiabetic, and Computational Studies

AA Adeleke, SD Oladipo, RC Luckay… - …, 2024 - Wiley Online Library
In this study, three Schiff base compounds,(E)‐N‐(4‐bromophenyl)‐1‐(2‐nitrophenyl)
methanimine (L1),(E)‐2‐((mesitylimino) methyl) phenol (L2), and (E)‐N‐(4‐bromophenyl)‐1 …

Exploring the anti-diabetic activity of benzimidazole containing Schiff base derivatives: In vitro α-amylase, α-glucosidase inhibitions and in silico studies

A Shakoor, G Fareed, I Ahmad, AA Elhenawy… - Journal of Molecular …, 2025 - Elsevier
The current study explores the anti-diabetic potential of some Schiff bases containing
benzimidazole scaffold. These derivative were synthesized by refluxing sodium metabisulfite …

Synthesis of novel hydrazide Schiff bases with anti-diabetic and anti-hyperlipidemic effects: in-vitro, in-vivo and in-silico approaches

WU Islam, A Khan, F Khan, S Ullah… - Journal of …, 2024 - Taylor & Francis
The increasing global incidence of non-insulin-dependent diabetes mellitus (NIDDM)
necessitates innovative therapeutic solutions. This study focuses on the design, synthesis …

Exploring the Potential Biological Activities of Pyrazole-Based Schiff Bases as Anti-Diabetic, Anti-Alzheimer's, Anti-Inflammatory, and Cytotoxic Agents: In Vitro …

AM Naglah, AA Almehizia, AS Al-Wasidi, AS Alharbi… - Pharmaceuticals, 2024 - mdpi.com
In this innovative research, we aim to reveal pyrazole-based Schiff bases as new multi-target
agents. In this context, we re-synthesized three sets of pyrazole-based Schiff bases, 5a–f, 6a …

Synthesis of benzimidazoles containing piperazine ring as potential therapeutic agents against diabetes mellitus and antioxidant activities

M Özil, KM Khan, N Baltaş, A Wadood, A Samad… - Journal of Molecular …, 2024 - Elsevier
Abstract We synthesized a novel 6-(4-substitue-piperazin-1-yl)-2-aryl-1H-benzimidazole
derivatives starting from 5-(4-substitue-piperazin-1-yl)-2-nitroaniline with different …

Exploring the anticancer potential of double-active pharmaceutical ingredient, metforminium ibuprofenate: Integrating in vivo and in silico investigations

KPS Hussan, J Layana, S Lekshmi, MS Thayyil… - Journal of Molecular …, 2024 - Elsevier
Rationale: A novel double active pharmaceutical ingredient (d-API), metforminium
ibuprofenate (MtHIb) was synthesised by combining metformin hydrochloride (MtHCl) and …

DFT calculations, molecular docking, in vitro antimicrobial and antidiabetic studies of green synthesized Schiff bases: as Covid-19 inhibitor

G Saranya, K Devendraprasad… - Journal of …, 2023 - pubmed.ncbi.nlm.nih.gov
In this investigation, we synthesized Schiff bases 2-(2-methoxyphenoxy)-N-(4-
methylbenzylidene) ethanamine, N-(4-methoxybenzylidene)-2-(2-methoxyphenoxy) …