Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic …
M Maes, M Kubera, I Mihaylova, M Geffard… - Journal of affective …, 2013 - Elsevier
OBJECTIVE: There is evidence that major depression is characterized by oxidative and
nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune …
nitrosative stress (O&NS). The aim of this study is to examine IgM-mediated autoimmune …
A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that …
This paper reviews the body of evidence that major depression is accompanied by a
decreased antioxidant status and by induction of oxidative and nitrosative (IO&NS) …
decreased antioxidant status and by induction of oxidative and nitrosative (IO&NS) …
IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive …
M Maes, I Mihaylova, M Kubera, JC Leunis… - Journal of affective …, 2011 - Elsevier
BACKGROUND: There is evidence that depression is accompanied by oxidative and
nitrosative stress (O&NS), as indicated by increased free radical levels, lipid peroxidation …
nitrosative stress (O&NS), as indicated by increased free radical levels, lipid peroxidation …
Construction of a nitro-oxidative stress-driven, mechanistic model of mood disorders: A nomothetic network approach
D Simeonova, D Stoyanov, JC Leunis, M Murdjeva… - Nitric Oxide, 2021 - Elsevier
Major depression is accompanied by increased IgM-mediated autoimmune responses to
oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts. These responses were not …
oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts. These responses were not …
Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of …
M Maes, I Mihaylova, M Kubera, M Uytterhoeven… - Journal of affective …, 2010 - Elsevier
BACKGROUND: Major depression is characterized by a decreased antioxidant status, an
induction of the inflammatory and oxidative and nitrosative (IO&NS) pathways and …
induction of the inflammatory and oxidative and nitrosative (IO&NS) pathways and …
Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications
Accumulating data have led to a re-conceptualization of depression that emphasizes the
role of immune-inflammatory processes, coupled to oxidative and nitrosative stress (O&NS) …
role of immune-inflammatory processes, coupled to oxidative and nitrosative stress (O&NS) …
Immune mechanisms linked to depression via oxidative stress and neuroprogression
N Bakunina, CM Pariante, PA Zunszain - Immunology, 2015 - Wiley Online Library
Emerging evidence suggests a significant role for inflammation and oxidative stress as main
contributors to the neuroprogression that is observed in major depressive disorder (MDD) …
contributors to the neuroprogression that is observed in major depressive disorder (MDD) …
Upregulation of the nitrosylome in bipolar disorder type 1 (BP1) and major depression, but not BP2: Increased IgM antibodies to nitrosylated conjugates are …
M Maes, D Simeonova, D Stoyanov, JC Leunis - Nitric Oxide, 2019 - Elsevier
Objective Major depression (MDD) and a lifetime history of MDD are characterized by
increased nitrosylation, while bipolar disorder type 1 (BP1), but not BP2, is accompanied by …
increased nitrosylation, while bipolar disorder type 1 (BP1), but not BP2, is accompanied by …
[PDF][PDF] The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression
M Maes - Neuroendocrinology letters, 2008 - nel.edu
This paper hypothesizes that inflammatory, oxidative and nitrosative (IO&NS) pathways, and
an increased translocation of LPS from gram-negative bacteria are causally related to …
an increased translocation of LPS from gram-negative bacteria are causally related to …
Oxidant/antioxidant imbalance is an inherent feature of depression
Abstract Background 50% to 60% of the people who have recovered from the first episode of
depression experience a relapse. The immune system of the people suffering from …
depression experience a relapse. The immune system of the people suffering from …
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