Objective Inherited congenital anomalies in tooth number, particularly hypodontia are
relatively common. Although substantial progress has been made that permits a better …

Hypodontia, the congenital absence of one or a few permanent teeth, is one of the most
frequent alterations of the human dentition. Although hypodontia does not represent a public …

Multiple previous reports confirm that several missense alleles of MSX1 exhibit Mendelian
inheritance of an oligodontia phenotype (agenesis of more than six secondary teeth besides …

OBJECTIVE: The MSX1 gene plays a key role in odontogenesis regulation, particularly
during early stages. Since only a few genetic variants have thus far been associated with …

Congenital tooth agenesis is caused by mutations in the MSX1, PAX9, WNT10A, or AXIN2
genes. Here, we report a Japanese family with nonsyndromic tooth agenesis caused by a …

MSX1 mutations have been reported in four unrelated families with autosomal dominant
tooth agenesis. In one family, some individuals also had cleft lip and/or palate. We have …

OBJECTIVE: Tooth agenesis is the most common developmental anomaly of the human
dentition, with aetiology involving both genetic and environmental factors. The aim of the …

Hypodontia, congenital lack of one or a few teeth, is an autosomally inherited dominant trait.
Homeobox genes MSX1 and MSX2 are expressed in presumptive dental tissues at the …

Mutations of MSX1 have been associated with nonsyndromic hypodontia. To seek the
causal gene mutation sites in a family with nonsyndromic oligodontia, whole‐exome …

MSX1 has a critical role in craniofacial development, as indicated by expression assays and
transgenic mouse phenotypes. Previously, MSX1 mutations have been identified in three …