Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by
dementia and memory loss for which no cure or effective prevention is currently available …
dementia and memory loss for which no cure or effective prevention is currently available …
Amyloid-β aggregation on model lipid membranes: An atomic force microscopy study
Amyloid fibril formation is generally associated with many neurodegenerative disorders,
including Alzheimer's disease (AD). Although fibril plaque formation is associated with …
including Alzheimer's disease (AD). Although fibril plaque formation is associated with …
[HTML][HTML] Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease
Amyloid-beta peptides (Aβ), implicated in Alzheimer's disease (AD), interact with the cellular
membrane and induce amyloid toxicity. The composition of cellular membranes changes in …
membrane and induce amyloid toxicity. The composition of cellular membranes changes in …
Amyloid and membrane complexity: The toxic interplay revealed by AFM
Lipid membranes play a fundamental role in the pathological development of protein
misfolding diseases. Several pieces of evidence suggest that the lipid membrane could act …
misfolding diseases. Several pieces of evidence suggest that the lipid membrane could act …
Amyloid-forming proteins alter the local mechanical properties of lipid membranes
KA Burke, EA Yates, J Legleiter - Biochemistry, 2013 - ACS Publications
A diverse number of diseases, including Alzheimer's disease, Huntington's disease, and
type 2 diabetes, are characterized by the formation of fibrillar protein aggregates termed …
type 2 diabetes, are characterized by the formation of fibrillar protein aggregates termed …
Alzheimer Aβ peptide interactions with lipid membranes: fibrils, oligomers and polymorphic amyloid channels
F Tofoleanu, NV Buchete - Prion, 2012 - Taylor & Francis
Fibrillar aggregates of misfolded amyloid proteins are involved in a variety of diseases such
as Alzheimer disease (AD), type 2 diabetes, Parkinson, Huntington and prion-related …
as Alzheimer disease (AD), type 2 diabetes, Parkinson, Huntington and prion-related …
The two-fold aspect of the interplay of amyloidogenic proteins with lipid membranes
A Relini, O Cavalleri, R Rolandi, A Gliozzi - Chemistry and physics of lipids, 2009 - Elsevier
Investigating the pathways leading to the formation of amyloid protein aggregates and the
mechanism of their cytotoxicity is fundamental for a deeper understanding of a broad range …
mechanism of their cytotoxicity is fundamental for a deeper understanding of a broad range …
[HTML][HTML] Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy
The ability of amyloid-β peptide (Aβ) to disrupt membrane integrity and cellular homeostasis
is believed to be central to Alzheimer's disease pathology. Aβ is reported to have various …
is believed to be central to Alzheimer's disease pathology. Aβ is reported to have various …
Membrane domain modulation of Aβ 1–42 oligomer interactions with supported lipid bilayers: an atomic force microscopy investigation
Alzheimer's disease is a devastating pathology affecting an increasing number of individuals
following the general rise in life expectancy. Amyloid peptide Aβ1–42 has been identified as …
following the general rise in life expectancy. Amyloid peptide Aβ1–42 has been identified as …
Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease
The association of the amyloid-β (Aβ) peptide with cellular membranes is hypothesized to be
the underlying phenomenon of neurotoxicity in Alzheimer's disease. Misfolding of proteins …
the underlying phenomenon of neurotoxicity in Alzheimer's disease. Misfolding of proteins …