Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding

MM Wirth, SQ Giraudo - Peptides, 2000 - Elsevier
Agouti-related protein (Agrp) is an endogenous melanocortin-4 receptor antagonist
implicated in the regulation of food intake. Effects of Agrp on feeding under varying …

Effect of Agouti-related protein delivered to the dorsomedial nucleus of the hypothalamus on intake of a preferred versus a non-preferred diet

MM Wirth, SQ Giraudo - Brain research, 2001 - Elsevier
Agouti-related protein (Agrp), a high-affinity antagonist of the melanocortin-3/4 receptors,
increases feeding when administered centrally. Previous studies have shown that this …

Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)

XY Lu, JR Nicholson, H Akil, SJ Watson - Neuroreport, 2001 - journals.lww.com
Agouti-related protein (AGRP) is a newly identified orexigenic peptide that acts as an
endogenous antagonist of melanocortin receptors MC3 and MC4. The present study …

Effects of Agouti‐Related Protein on Metabolism and Hypothalamic Neuropeptide Gene Expression

J Korner, S Wissig, A Kim, IM Conwell… - Journal of …, 2003 - Wiley Online Library
The hypothalamic melanocortin system regulates feeding in part through interaction of the
appetite stimulating peptide, agouti‐related protein (AGRP), and the anorectic peptide, α …

Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor

MS Kim, M Rossi, CR Abbott, SH AlAhmed, DM Smith… - Peptides, 2002 - Elsevier
Intracerebroventricular (ICV) injection of Agouti related protein (AgRP), an endogenous
melanocortin 3 and 4 receptor (MC3/4-R) antagonist, produces a prolonged increase in food …

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

M Rossi, MS Kim, DGA Morgan, CJ Small… - …, 1998 - academic.oup.com
Agouti-related protein (Agrp) is present in rat and human hypothalamus and is structurally
related to agouti protein. Over-expression of either of these proteins results in obesity …

Agouti‐related protein: appetite or reward?

PK Olszewski, K Wickwire, MM Wirth… - Annals of the New …, 2003 - Wiley Online Library
Agouti‐related protein (AgRP) is an orexigenic peptide that acts as an antagonist of the
melanocortin‐3 and‐4 receptors in the hypothalamus. Studies suggest that the melanocortin …

Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals

CJ Small, MS Kim, SA Stanley, JRD Mitchell… - Diabetes, 2001 - Am Diabetes Assoc
The melanocortin receptor (MC3-R and MC4-R) antagonist, agouti-related protein (AGRP),
is a potent stimulant of food intake. We examined the effect of chronic intracerebroventricular …

Immediate and prolonged patterns of Agouti-related peptide-(83–132)-induced c-Fos activation in hypothalamic and extrahypothalamic sites

MM Hagan, SC Benoit, PA Rushing… - …, 2001 - academic.oup.com
Several lines of evidence substantiate the important role of the central nervous system
melanocortin 3-and 4-receptor (MC3/4-R) system in the control of food intake and energy …

Combined Blockade of Both μ- and κ-Opioid Receptors Prevents the Acute Orexigenic Action of Agouti-Related Protein

S Brugman, DJ Clegg, SC Woods, RJ Seeley - Endocrinology, 2002 - academic.oup.com
Agouti-related protein (AgRP) is an endogenous antagonist at the melanocortin 3 and 4
receptor in the hypothalamus. Central administration of AgRP produces a robust increase in …