Specificity of neurotrophin factor signaling is dictated through the action of Trk receptor
tyrosine kinases. Once activated, Trk receptors are internalized and targeted for …

Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling,
trafficking, and degradation of the receptors. However, the in vivo consequences of Trk …

Target‐derived neurotrophins regulate neuronal survival and growth by interacting with cell‐
surface tyrosine kinase receptors. The p75 neurotrophin receptor (p75NTR) is coexpressed …

Neurotrophins are a family of soluble ligands that promote the survival and differentiation of
peripheral and central neurons and regulate synaptic function. The two neurotrophins, brain …

Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by
neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory …

Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects
of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 …

Neurotrophins are a family of growth factors playing key roles in the survival, development,
and function of neurons. The neurotrophins brain‐derived neurotrophic factor (BDNF) and …

Endocytic trafficking of signaling receptors to alternate intracellular pathways has been
shown to lead to diverse biological consequences. In this study, we report that two …

Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk
receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor …

The four mammalian neurotrophins—NGF, BDNF, NT-3 and NT-4—each bind and activate
one or more of the Trk family of receptor tyrosine kinases. Through these receptors …