A major contribution to the mechanical strength of the heart is provided by a continuous
fibrillar collagen network embracing individual myocytes and forming an interstitial and …

The extracellular matrix of the myocardium contains an elaborate structural matrix composed
mainly of fibrillar types I and III collagen. This matrix is responsible for the support and …

Ischemic cardiomyopathy refers to a significant impairment of left ventricular function, a
condition resulting from atherosclerotic coronary artery disease. The left ventricular ejection …

The myocardium consists of a muscle fibre array surrounded and interspersed by a network
of connective tissue, principally collagen, which maintains the functional integrity of the …

OBJECTIVES.: The aim of this study was to quantify total collagen and the type I/type III
collagen ratio and their localization in hearts with dilated cardiomyopathy. BACKGROUND …

Eighteen different collagen types have now been identified, at least five of which are found
in the extracellular matrix of the heart. The interstitial collagens, types I and III are the most …

The extracellular matrix is often viewed as the scaf-folding that supports the cellular
elements of various tissues. It is now recognized that in addition to their structural functions …

A collagen network, composed largely of type I and III fibrillar collagens, is found in the
extracellular space of the myocardium. This network has multiple functions which includes a …

In this study we report the changes of interstitial collagen in the human non-infarcted
interventricular septum after a myocardial infarction as well as in hypertrophic human hearts …

MMP activity with disruption of structural collagen has been implicated in the
pathophysiology of dilated cardiomyopathy. To examine the role of this enzyme in cardiac …