Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Introduction: Epigenetics is the study of reversible modifications to chromatin and their
extensive and profound effects on gene regulation. To date, the role of epigenetics in …

Epigenetic modifications and regulators represent potential molecular elements which
control relevant physiological and pathological features, thereby contributing to the natural …

Epigenetic mechanisms control gene expression in a way that is stably propagated over
multiple cell divisions, but which is also flexible enough to respond to environmental …

Cancer evolution at all stages is driven by both epigenetic abnormalities as well as genetic
alterations. Dysregulation of epigenetic control events may lead to abnormal patterns of …

A myriad of diseases is caused or characterized by alteration of epigenetic patterns,
including changes in DNA methylation, post-translational histone modifications, or chromatin …

Growing cancer incidence and mortality worldwide demands development of accurate
biomarkers to perfect detection, diagnosis, prognostication and monitoring. Urologic …

Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …

Epigenetic alterations are considered to be very influential in both the normal and disease
states of an organism. These alterations include methylation, acetylation, phosphorylation …

Epigenetics is a rapidly growing field of biology that studies the changes in gene expression
that are not due to alterations in the DNA sequence but rather the chemical modifications of …