Current epidemiologic and genetic data suggest the hypothetical paradigm that prostate
cancer occurs in three forms: sporadic, familial, and hereditary (Figure 1). Sporadic cases …

Previous studies have demonstrated familial clustering of prostate cancer. To define the
nature of this familial aggregation and to assess whether Mendelian inheritance can explain …

Genetic factors and their inter-actions with environmental conditions and internal
microenvironment influence the prostate cancer (PC) development, so that gene expression …

BACKGROUND To identify associations of other cancers with hereditary prostate cancer
(HPC) we estimated relative risks (RRs) of 36 different cancers in relatives of prostate cancer …

OBJECTIVE:: To evaluate the clinical impact of different definitions of hereditary prostate
cancer (PCa), the relative risk (RR) of relatives of PCa cases and differences in clinical …

The hereditary predisposition to prostate cancer is rare and accounts for< 5% of cases.
Except for younger age at diagnosis, no phenotypic features have been clearly associated …

This presentation reviews data on the familial component of prostate cancer and evidence to
support a role of genetic susceptibility in this common and complex disease. Data from case …

Current status of linkage studies in hereditary prostate cancer Page 1 BJU Internationai (2000),
86, 659-669 REVIEW Current status of linkage studies in hereditary prostate cancer MK …

The incidence of prostate cancer (CaP) and its increase in the last 10 years vary both from
country to country and according to the ethnic group, with the highest incidence reported for …

A genetic component in prostate cancer has been recognized since decades. Through
numerous epidemiological and molecular biological studies, much evidence has …