The prospect of using linkage disequilibrium (LD) for fine-scale mapping in humans has
attracted considerable attention, and, during the validation of a set of single-nucleotide …

The mitochondrial genome was among the earliest molecules to be surveyed for variation at
the DNA level in humans. Some of the advantages offered by mtDNA in the pre-PCR era …

Admixture mapping (also known as" mapping by admixture linkage disequilibrium," or
MALD) has been proposed as an efficient approach to localizing disease-causing variants …

The central preoccupation of human genetics is an effort to understand the genotypic basis
of human phenotypic diversity. Although recent progress in identifying the genes that, when …

Mendelian randomization (MR) is increasingly used to make causal inferences in a wide
range of fields, from drug development to etiologic studies. Causal inference in MR is …

Admixture between populations originating on different continents can be exploited to detect
disease susceptibility loci at which risk alleles are distributed differentially between these …

Transcribed regions in the human genome differ from adjacent intergenic regions in
transposable element density, crossover rates, and asymmetric substitution and sequence …

The transmission/disequilibrium (TD) test (TDT), proposed, by Spielman et al., for binary
traits is a powerful method for detection of linkage between a marker locus and a disease …

In human populations that have remained of small and constant size, high levels of linkage
disequilibrium (LD) are generated by genetic drift (Slatkin 1994; Laan and Pääbo 1997) …

The design and feasibility of whole-genome–association studies are critically dependent on
the extent of linkage disequilibrium (LD) between markers. Although there has been …